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Guesthouse vacation rentals in Los Santos Province

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Top-rated guesthouse rentals in Los Santos Province

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Top guest favorite
Palm trees stand gracefully on a lush green hillside, leading to a welcoming casita with a tiled roof. The vibrant landscape showcases tropical foliage under a clear sky, indicating a serene and natural environment.
Guesthouse in Pedasi
5 out of 5 average rating, 31 reviews

A Remote Paradise in nature - Ocean View

'Tres-Palmas' sea and nature at its best! A remote hideaway on the Pacific Coast of Panama, but yet close enough to nearby towns and entertainment, Tres Palmas is the perfect place for an invigorating holiday. It is more than just a place to stay, we offer our guests personalized attention through fully equipped facilities and services for your comfort and well being. We enjoy getting to know our guests, sharing life stories and greeting you with an authentic smile for an unforgettable stay.

The exterior of a cozy one-bedroom cabana is shown, featuring a traditional tiled roof and a blend of brick and stucco walls. A green chair is positioned on the porch, which overlooks a grassy area. A thatched rancho is visible in the background, surrounded by lush greenery.
Guesthouse in Cañas

Cozy & quiet cabin in Cañas

It is a cozy one-bedroom unit, with a closet, a bathroom with separated toilet area, a porch and a rancho. Nestled amidst the serene hills of Canas, the property offers a tranquil retreat with a picturesque ocean view. Wake up to the enchanting melodies of howler monkeys and local birds, immersing yourself in the beauty of nature every morning. While the cabana doesn’t have its own kitchenette, fret not! You’ll have access to a nearby fully equipped community kitchen, shared between 2-3 people.

A spacious bedroom is presented with a large bed topped with neutral bedding and two decorative pillows. A surfboard is displayed on the wall above the bed, while a wooden door adds character. A small table, decorative plants, and framed artwork contribute to the room's aesthetic.
Guesthouse in Cambutal

Alma Residencia - Jungle & 5 minute walk to beach

Alma Residencia is a calm & comfortable retreat for surfers, artists, and nature lovers. Nestled between jungle mountains and the ocean, our space offers a simple, peaceful base to rest, create, & explore Cambutal. WiFi, A/C, & the convenience of Pizzería Madera (Jan - May) located on-site. Spend your days surfing, hiking, or spotting wildlife, and your evenings stargazing under clear skies. A warm, natural escape—just minutes from the beach and surrounded by the beauty of the jungle.

Guesthouse in Cambutal

Tiger Beach Cottage @ Los Buzos

A relaxing getaway right across the beach for anyone looking for time in paradise. Located at Los Buzos Resort and its world famous fishing & adventure lodge where guests have direct access to the many activities and amenities it has to offer like its 400 acre private nature reserve Parque Los Buzos where guests can experience the lush Panamanian wilderness and wildlife on more than 40k of trails. Los Buzos has many thrilling activities waiting. We live where the adventure is.

Top guest favorite
Guesthouse in Playa Los Destiladeros
5 out of 5 average rating, 10 reviews

Ginger Apartment/House for a violinist

Relax in this unique and peaceful getaway in a private neighborhood. Just a 5-minute walk to the beach, from the house you can hear the water of the creek and the birds singing in the trees, allowing you to enjoy the nature and tranquility of the surroundings. The accommodation features a large terrace with a barbecue area, an outdoor bathroom and shower, and a deck overlooking the creek. Ideal for nature lovers, remote work, surfing, yoga, meditation, hiking, and fishing.

A cozy sleeping area is featured with a bunk bed above a spacious bed. A decorative plant is positioned nearby, and light-colored linens are visible on both beds. A wall-mounted air conditioning unit provides comfort, complemented by a calming blue accent wall.
Guesthouse in Isla Cañas

PUNTA CAÑAS

Las Cabañas de Isla Cañas, son 2 habitaciones diseñadas para que puedas disfrutar de la relajación en medio de la naturaleza que tanto mereces. Nos encanta que te sientas en casa, por eso hemos acondicionado una de nuestras cabañas con cocina básica que tiene refrigerador, estufa y los utensilios de cocina, además puedes hacer BBQ, tienes hamacas para que puedas disfrutar tu estancia con tu familia, estamos ubicados a solo 7 minutos caminando de la Playa de Isla Cañas.

Guest favorite
A refreshing swimming pool sits in the foreground, complementing the rustic building behind it. Lush greenery and potted plants surround the area, enhancing the natural setting. A shaded patio area with outdoor seating is visible, offering a serene environment for relaxation.
Guesthouse in La Enea
4.96 out of 5 average rating, 49 reviews

Country House with Pool in La Enea de Guararé

Far from the capital city, come and enjoy Panamanian folklore in a rustic but cozy space, living an indigenous experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Port of Guararé where you can enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian skirts.

A cozy sleeping area features a plaid bedspread on a spacious bed. Adjacent to the bed, a small wooden shelf provides a convenient surface. A fan is mounted on the wall, and natural light filters in through a nearby window adorned with bamboo blinds.
Guesthouse in Las Tablas

Accommodation in Las Tablas

Enjoy the simplicity of this quiet and central home. Just a 10-minute walk from Las Tablas village center, birthplace of Panamanian culture and folklore with its activities and festivities. It offers the basic services for short stays. The owner can provide information to the guest to visit nearby beaches and indicate means of transportation to visit nearby districts such as Pedasí and activities of interest in the province.

Guest favorite
A charming structure is framed by lush greenery, showcasing a rustic exterior with a terracotta roof and red accents. A small porch features a table and two chairs, inviting relaxation in this serene environment.
Guesthouse in Guararé
4.88 out of 5 average rating, 17 reviews

La Casita del Abuelo

This private place with full private bathroom is perfect for solo adventurers or a couple, seeking peace and relaxation in an authentic environment near the beach and town. This cute hideaway is located minutes’ walks from town and bus stop and about two miles from the nearest beach. It is a new, very clean, private, secure place, and it includes private use of an adjacent bohio with hammocks, barbecue grill, and bar.

A colorful hammock is draped between two wooden posts on a porch, surrounded by lush greenery. A person is seen resting peacefully, reclined with their back against the hammock. The setting invites relaxation and embodies a connection to nature.
Guesthouse in Cambutal
4.86 out of 5 average rating, 7 reviews

"La Jungla" Cabaña close to the beach

New room with shared kitchen and private bathroom close to the beach. You can enjoy all that Cambutal has to offer from this place. It has easy access so you dont need 4x4. Its located 500m from the beach, or 5 mins walking. The room has its own little green area and a large bathroom in the back. We try yo be close to nature and have a cool community here. We are happy to welcome new comers and old faces to Cambutal :)

Guesthouse in Cambutal
5 out of 5 average rating, 4 reviews

Casita Verde 411

Ocean View Jungle Casita • 500 m from 411 Surf Spot • Off-Grid Retreat 🌊🌴 Wake up to waves and tropical birds in our cozy Casita, just a 3-min walk from the famous 411 Surf Spot. Between lush rainforest and the Pacific, this off-grid retreat offers adventure and relaxation. Why You’ll Love It Here: Surf in the morning, relax in the hammock by day, and stargaze at night – far from crowds, surrounded by nature.

An open living area is showcased, featuring a comfortable sofa paired with modest coffee tables. Natural light enters through large windows, illuminating the tasteful decor. Visible kitchen and dining spaces can be seen in the background, enhancing the casual yet stylish ambiance.
Guesthouse in Playa Venao

Modern Casita just a short walk to the beach

Kick back and relax in this calm, stylish space. This newly built casita is 2 bedrooms and 1 bath. It has AC, outdoor shower and a washer and dryer. Relax on your private patio or stroll 2 min to a calm quiet beach. Still only 5 min by car to the heart of Playa Venao and all the surf, restaurants and bars that it has to offer

Popular amenities for Los Santos Province guesthouse rentals