House vacation rentals in Lauderdale County

Find and book unique houses on Airbnb

Top-rated house rentals in Lauderdale County

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Superhost

A modern living space features a ceiling fan and a wall-mounted television displaying streaming service options. A woven chair is positioned next to a wooden side table, with a decorative rug laid on the polished hardwood floor. Light-colored walls enhance the ambiance.

Home in Florence

4.89 out of 5 average rating, 168 reviews

Mid-City Modern - Super Convenient to Downtown

Whether you are travelling alone or are a group of up to four you will find Mid-City Modern comfy and cozy! Enjoy all Florence has to offer from your home base with us. Mid-City Modern is a newly renovated Mid-Century home, Aug 19', that has been brought beautifully into the modern era. Conveniently located in the heart of Florence and allows easy access to everything our city has to offer. Located in a quiet established neighborhood with an open lot and a small creek directly across the street.

Top guest favorite

A cozy living area features a stylish sofa with patterned cushions, two orange accent chairs, and a wooden coffee table. A flat-screen TV is mounted on the wall across from the seating. Natural light floods the space through nearby windows, highlighting the warm hardwood flooring.

Home in Florence

4.97 out of 5 average rating, 108 reviews

The Simpson Splendor - Downtown Florence, 7 Points

Kick back and relax in this calm, stylish space. The Simpson Splendor is conveniently located less than 3 blocks from UNA and Downtown Florence, in the heart of the Famous 7 Points area with many bars, eateries, and places to shop. A pull through driveway makes easy access for pulling boats to enjoy the magnificent TN River that is only 1.5 miles away or if you are in town working with trucks. Whether you are here for work, relaxation, or family, this historic town is sure to swoon your heart.

Superhost

A compact dining area features a wooden table set for two and surrounded by simple wooden chairs. Light enters through two windows, highlighting the neutral tones of the walls. A clock and artwork adorn the walls, adding subtle character to the space.

Home in Florence

4.85 out of 5 average rating, 272 reviews

Close to Hospital, Eastside Bungalow, (Dog + Fee)

A cozy spot during your stay for work, transition, or leisure? The Eastside Bungalow is the perfect match, just 4 blocks from the North Alabama Medical Center! Nestled in a developing neighborhood, it offers a full kitchen including a drip coffee maker (we supply the coffee), living/dining area, bath w/shower, Smart TV, Wi-Fi, and dogs welcome with a fenced backyard. Conveniently close to the hospital, conference center, and 5 minutes to shopping, dining, and Florence Harbor. Book now! 🏡🐾

Top guest favorite

A welcoming living area showcases a cozy sofa facing a mounted television. A floor lamp and side table add a touch of style, while decorative accents bring warmth. Natural light streams in through a window, illuminating the wooden walls and enhancing the inviting ambiance.

Home in Muscle Shoals

5 out of 5 average rating, 219 reviews

Bass & Birdie of the Shoals

Kick back and relax in this calm, stylish space. Come enjoy beautiful sunsets on your private deck while relaxing in a hot tub or sitting around the fire pit. Enjoy this cozy retreat only 1 mile from RTJ golf course, and 3 miles to the closest boat ramp. This home offers a kitchen with a coffee bar and wine cooler, interior/exterior TV, spacious walk-in shower and claw foot tub. We also offer boat and RV utility hook ups. Enjoy a wide variety of eating and entertainment 10-15 minutes away.

Guest favorite

The cozy living room features a light-colored sofa and a large recliner. A flat-screen TV is mounted above a white brick fireplace. Natural light enters through a large window, complemented by neutral curtains. A dining area with a beige table is also visible.

Home in Florence

4.92 out of 5 average rating, 166 reviews

The Sherrod. Cute, Cozy & Comfy Cottage.

Welcome! Enjoy your stay at this centrally-located home where you are within a few miles of all Florence Al has to offer. Cute 3 bedroom 1 bath home has been beautifully renovated with new flooring, paint & cute light fixtures. Enjoy the comfy living room while watching the 55 inch Smart Tv. Dine area offers seating for up to 6. Kitchen stocked with all you need to whip up a small meal or venture out to one of the the many nearby restaurants . All bedrooms have smart TVs. Wi-Fi available.

Guest favorite

A bright living room is showcased with dual dark sofas adorned with decorative pillows. A wooden coffee table sits centrally, featuring a plant and decorative items. Natural light enters through the sheer curtains, complementing the inviting red front door in the background.

Home in Florence

4.9 out of 5 average rating, 116 reviews

Cozy Home at 7 Points

Welcome to our charming rental in historic Florence, Alabama. Explore downtown's boutiques and eateries, UNA's campus, and McFarland Park's scenic beauty nearby. Cozy bedrooms, well-equipped kitchen, and a memorable stay await. Located just a stone's throw away from downtown Florence, UNA, and the Tennessee River, you'll be delighted to explore the vibrant streets lined with boutique shops, art galleries, and an array of delicious eateries as well as the University and park.

Superhost

A welcoming living area features a light-colored sofa adorned with decorative cushions, a small white coffee table, and a comfortable accent chair. Natural light filters through two windows, highlighting the refinished wooden flooring. A stylish light fixture hangs from the ceiling, adding a modern touch.

Home in Florence

4.91 out of 5 average rating, 249 reviews

The Mellow Mushroom

You'll love the Mellow Mushroom! The home is a beautifully decorated Boho style space located less than a mile from the University and Downtown! Whether you're in town for work or a vacation or just visiting friends and family this place will feel like home. We provide coffee and popcorn to save you a trip to the store, if you need anything though there is a Dollar General and Grocery Store less than a mile from the place. I offer instant booking. And self check-in for guests.

Top guest favorite

The image features a hot tub with bubbling water, surrounded by a stone patio. In the background, a dining area is seen with a table, four chairs, and a patio umbrella. Soft lighting enhances the ambiance, along with decorative planters placed nearby.

Home in Florence

4.98 out of 5 average rating, 258 reviews

Charming River Rock house/hot tub & backyard oasis

Embrace the charm of this renovated 2-bed, 1-bath River Rock house. Relax in the private backyard oasis with a hot tub, dining area, patio umbrella, heater, lighting, and a seasonal outdoor shower (shower closed Oct. - May). Ample off-street parking, perfect for boats and RVs. Security cameras are located outside with a monitor to view the cameras located in the laundry room. Minutes from downtown and Muscle Shoals, this retreat offers modern comfort in a convenient location.

Top guest favorite

The exterior of the house features a welcoming entrance with a covered porch and decorative railing. An American flag is proudly displayed. Lush greenery surrounds the property, creating a tranquil environment, while the concrete driveway leads up to the main entrance.

Home in Florence

4.97 out of 5 average rating, 141 reviews

Inglenook

Our home consists of 3 bedrooms and 2 bathrooms. It is a newer built house, less than 10 years. There is a beautiful kitchen with everything you need stocked. The home has many outdoor options; a large covered deck, covered patio and a quaint front porch. It is centrally located to everything around Florence. It is about a 10 minute drive to our growing downtown area. Then about 20 minutes to our surrounding towns: Muscle Shoals, Sheffield and Tuscumbia.

Guest favorite

The exterior of the retreat features a charming white façade with decorative trim. A light purple front door welcomes guests, framed by large windows with flower boxes. A lush green lawn and a well-established tree enhance the serene outdoor setting.

Home in Florence

4.99 out of 5 average rating, 113 reviews

The Pine Spring Knoll

Welcome to the Pine Spring Knoll! This European inspired retreat offers a luxurious 2-bed, 1-bath experience with curated design touches throughout. Unwind and enjoy the private balcony, gather around the fire pit for a cozy evening under the stars, relax in the soaking tub, cuddle up in the living room with a book or watch your favorite movie. Experience the perfect blend of comfort and style in this charming getaway right in downtown Florence.

Top guest favorite

A comfortable sitting room features a light-colored sofa adorned with various textured cushions. A rustic coffee table is centered in the space, complemented by a decorative bowl. Natural light enters through large windows, enhancing the cozy seating arrangement and warm wooden accents.

Home in Florence

4.97 out of 5 average rating, 105 reviews

Sandstone Cottage in Downtown Florence

The Sandstone Cottage is located in downtown Florence, Alabama minutes away from the University of North Alabama, 7 points, and Court Street. It includes a sitting room, cozy den, spacious kitchen, 3 bedrooms, and 2 full baths, as well as a private backyard complete with a covered deck and outdoor seating. Kick back and relax in this newly renovated and styled home designed to provide a unique and relaxing space to enjoy the best of the Shoals!

Guest favorite

A spacious room features two twin beds adorned with neutral bedding, flanked by wooden nightstands and lamps. A small table sits between the beds. A light-colored area rug covers the floor, and a window provides natural light, complemented by wall-mounted lighting.

Home in Florence

4.78 out of 5 average rating, 130 reviews

Historic Court St Home steps from UNA and downtown

This home has a long and unique history dating back to the 1800's. It is practically on UNA's campus, just a 2 minute walk to Starbucks & Chick-fil-A to the north, and a 5 minute walk to the restaurants and shops of downtown Florence to the south. Upstairs, there are 2 bedrooms, 1 bathroom and a coffee nook with microwave and fridge. Downstairs there is more living space with a dining table and living room. New cleaning company as of 11/24!