
Vacation rentals in La Mesilla
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in La Mesilla
Guests agree: these stays are highly rated for location, cleanliness, and more.

Sky-filled 'Studio Cielito' @ Rancho Los Sonadores
Welcome to Studio Cielito - a desert-inspired cottage designed with bath lovers in mind. Curated with vintage touches, luxury linens, and everything you need to relax and rejuvenate near the magical Sangre de Cristo Mountains. Just 8 mins from Meow Wolf and 14 mins from The Plaza, but surrounded by nature with a country feel. If your dates are not avail, click on our profile for our other rentals. **Due to COVID-19, we are asking that all guests be vaccinated to help keep our community safe.

Breathtaking Views, Privacy next to Four Seasons
One of the more private casitas in Pueblo Encantado, offering sweeping views & stargazing just across from the Four Seasons. Set within a 95-acre community in the rolling Tesuque foothills, this light-filled retreat is only a 10-minute drive to the Plaza. Enjoy a peaceful patio w/ beautiful views of the Jemez Mountains. Located at the end of a two-casita building with no parking/cars in front, just rolling hills. A perfect place to relax and experience the quiet beauty of northern Santa Fe.

Happy Ram: Views! Beautiful. Peaceful. Upscale.
Want a unique, stylish, peaceful stay in Santa Fe? Happy Ram is an architect-designed, professionally decorated home on a 6.4-acre estate. Huge views of the Sangre de Cristo mountains from every room. Thick rammed earth walls create incredible quiet. Bedrooms on opposite sides of the home for maximum privacy. Patio with fireplace. Just 5 minutes to hip Tesuque Village, 6 to Four Seasons Resort, 11 to Santa Fe Opera, 14 to Santa Fe Plaza. Make your Santa Fe dream vacation come true! STRO-40172

Santa Fe Super Dome
*READ ALL property info BEFORE BOOKING* Stay in the coolest spot in the Santa Fe area. New deck! Glamping dome on 8 private acres of ancient canyons, just south of Santa Fe on Hwy 14. Enjoy 360 degree views of every mountain chain in the area - Sangre de Christos, Jemez, Sandias, Ortiz, Manzanos. You even get Mt. Taylor, silhoutted in exquisite sunsets. This is the ultimate high desert glamping experience. Indoor plumbing, heat, stone shower, king bed. Personal Chef services available.

Hilltop Nest
Kick back and relax in this stylish cabin in the forest. Hilltop location with forever views. Just off scenic Route 66 (Hwy 50), up a steep (but short) driveway, sits a 2-bedroom log cabin with plenty of birdsong and pine trees, a porch surrounded by views and furnished with a grill for outdoor dining. Five miles east is the village of Pecos with the Pecos River for fishing, hiking, and exploring. Sixteen miles north is the legendary city of Santa Fe packed with world-class art and culture

Cozy Forest Escape with Private Hot Tub
Escape to a Peaceful Forest Retreat Nestled on a 1.5-acre wooded lot, this relaxing cabin offers the perfect retreat for nature lovers and adventure seekers. Located adjacent to the Valles Caldera National Preserve, our property boasts: - Relaxing Hot Tub: Unwind among the pines - Wildlife watching opportunities - Short drive to Fenton Lake for top-notch fishing - Modern comforts for a peaceful stay - Proximity to outdoor activities for all seasons: hiking, biking, fishing, and skiing

Raven House
This cozy 2-story home sits on 10 acres in the Chama River Valley. A seasonal creek runs along edge of land with amazing mountain views. Ideal for a single artist, couple or small family. Hiking + hot springs nearby, including Ghost Ranch, Poshuouingue ruins & Ojo Caliente Springs! Most pets are welcome (for a pet fee). It's helpful to check in on it, however, due to our contained pups further back on the land. Open to longer stays at discounted price. Write about either to discuss!

River Oasis | Hot Springs Nearby
Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.

Charming Camper near Santa Fe
Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

Casa Encantada, Charming Northern New Mexico Adobe
Welcome to Casa Encantada! This charming historic adobe casa is the perfect getaway for those seeking an enchanting break from the bustle of city living. Nestled in the country, 20 miles north of downtown Santa Fe in the historic village of Nambe, this home is ideally situated for excursions to the many beautiful sites Northern New Mexico has to offer. Make Casa Encantada your base camp as you explore Santa Fe and beyond, then come home to a unique and comforting retreat.

Beautiful View
Nambé, New Mexico in Santa Fe County quiet rural setting. It is located 20 minutes from Historic Santa Fe, surrounded by Ancient Anasazi hiking trails and ruins. On the High Road to Taos. Enjoy the peace of the country. Safe and friendly. Romantic, comfortable ,within a private compound. All the amenities of home. Star filled nights, quaint, beautiful accommodations and a charming shared garden to relax and enjoy the beauty of the view of the Sangre de Cristo Mountains.

Estrella sanctuary - an Ojo Caliente retreat cabin
This solid wood cabin is tucked away in a large valley with tons of privacy. It’s been recently renovated and upgraded. The cabin has rustic charm with all the updated amenities one could desire. Perfect for a family vacation or for wondering souls hoping to find a place to decompress from life. *Ojo caliente spa IS accepting walk in’s for soaking and I was told it’s rarely at capacity so if you are hoping to soak it’s almost assured to happen :)
Popular amenities for La Mesilla vacation rentals
Other great vacation rentals in La Mesilla

High Moon 4 Ten Thousand Waves Way

River Retreat with a Hot Tub!

Sunshade

Charming Chimayo Getaway

Centrally Located Southwest Oasis-Sage Casita

"Casa Noor" located on the Rio Chama

Remodeled Cabin | Pecos River | WiFi | Decks

6-Acre Sanctuary|Dark Sky|Hot Tub|Dogs|Cowboy Pool
Destinations to explore
- Durango Vacation rentals
- Denver Vacation rentals
- El Paso Vacation rentals
- Colorado Springs Vacation rentals
- Breckenridge Vacation rentals
- Albuquerque Vacation rentals
- Northern New Mexico Vacation rentals
- Ruidoso Vacation rentals
- Ciudad Juárez Vacation rentals
- Aspen Vacation rentals
- Santa Fe Vacation rentals
- Vail Vacation rentals
- Santa Fe Plaza
- Ski Santa Fe
- Meow Wolf
- Sipapu Ski & Summer Resort
- Georgia O'Keeffe Museum
- Bandelier National Monument
- Museum of International Folk Art
- Santa Fe Farmers Market
- Santa Fe National Forest
- Rio Grande Gorge Bridge
- Hyde Memorial State Park
- Loretto Chapel
- The Cathedral Basilica Of St. Francis Of Assisi
- El Santuario De Chimayo
- Taos Plaza
- Pecos National Historical Park
- Valles Caldera National Preserve
- Bandelier National Monument
- Ghost Ranch





