Vacation rentals in La Mesilla

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Top-rated vacation rentals in La Mesilla

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Guest favorite
A bright dining area features a wooden table with several chairs, accompanied by a cozy seating arrangement beside a large fireplace. Natural light flows through the windows, enhancing the warm tones of the wooden beams and adobe walls.
Chalet in Santa Fe

Five Level Artist Retreat on Tano Road - Sleeps 8+

This five-level 4 bdrm 2 ba artist retreat has been freshly renovated to merge post modern style, easy comfort and traditional charm. Enjoy spectacular sunrises, sunsets and star gazing on the 5th level of the house while enjoying the warmth of a large fireplace. Special design touches include river rock lined showers, unique tile accents and the warmth of wood textures and finishes throughout. Only 15 minutes to the historic Santa Fe Plaza, this home has a lovely courtyard and plenty of parking

4.94 out of 5 average rating, 344 reviews
Top guest favorite
Guesthouse in Los Alamos

Mountain View Retreat | Peaceful & Cozy Escape

Comfortably accommodates 2 guests. A 3rd guest may be considered upon request/prior approval. Wake up to breathtaking Sangre de Cristo Mountain views in this cozy 350 sqft private casita—perfect for couples or solo travelers seeking comfort, calm, and a peaceful getaway. Enjoy a bright, thoughtfully designed space with privacy, private entrance, and fully equipped kitchen. Sip coffee with mountain views and unwind in a peaceful setting guests love for its comfort, cleanliness, and atmosphere.

4.98 out of 5 average rating, 135 reviews
Guest favorite
Guesthouse in Santa Fe

Desert Hideaway - Private Casita Suite

Brand new shower!! Experience the ultimate desert escape at our guest suite, nestled amidst majestic mountains. This charming oasis offers a serene retreat with a queen bed, full kitchen, bath, and dining room. Embrace the tranquility of the desert landscape as you relax in the cozy suite & savor panoramic mountain views. Immerse yourself in nature's beauty embarking on thrilling adventures. Discover the perfect balance between comfort & breathtaking surroundings in this idyllic desert haven.

4.81 out of 5 average rating, 129 reviews
Guest favorite
A series of images showcases the guest house and farm setting. The large bedroom features a king bed and natural light from a window. The farmhouse kitchen includes wooden cabinets and cooking utensils. The organic garden reveals rows of vegetables, while a chicken interacts with a simple nesting area.
Farm stay in Santa Fe

Nambé Farm Stay

Join us on our organic veggie farm, 20 minutes north of Santa Fe and 25 minutes from Los Alamos, in beautiful Nambé. Our guest house is a stand alone casita with a fenced-in yard for your dogs, on our 5 acre working-farm property. The space has a large bedroom with king bed and writing desk, a living room with a comfy leather couch, tv with streaming capacity, a large bathroom with a tub, shower, washer/dryer, and a farmhouse kitchen to cook in. There is WiFi through-out. Pop-up cot available.

4.92 out of 5 average rating, 127 reviews
Top guest favorite
A bright bedroom features a queen bed adorned with a colorful patterned quilt and several decorative pillows. An antique dresser stands beside the bed, and a lamp is positioned on the nightstand. Natural light filters through a window, illuminating the space.
Cottage in Los Alamos

Los Alamos Casita de Cielo

Our private-entry casita is nestled in the pines, boasts a canyon view, and is only a 5 minute drive to LANL, the Fuller Art Lodge, and the historic district. You’ll enjoy a luxurious queen bed, spa-like bath, and fully equipped kitchenette (stocked with treats!). Clerestory windows keep the space light and bright. Set back on the lot with a private patio and driveway. Easy access to Bandelier, Pajarito Ski Mountain, and downtown via shuttle or car. Let our casita be your home away from home!

4.99 out of 5 average rating, 351 reviews
Top guest favorite
The spacious studio features traditional adobe architecture with exposed wooden beams. A colorful woven blanket adorns the seating area, complemented by wooden furniture. A vintage lamp and decorative pieces add character. A cozy sleeping area is visible, along with natural light filtering through the window.
Guest suite in Santa Fe

The Family Casita Santa Fe/ Pojoaque

The Family Casita is the guest wing to a family home with a private separate entrance. This is a large elegant adobe with thick walls that keep it cool in the summer and provide old world charm. A very spacious 900 square foot studio space, it has two original fireplaces, one in the eat-in kitchen, and one in the main room. There is a beautiful hand painted king sized bed and a Euro Lounger (that converts to a double bed), separated by a privacy wall. Dogs welcome. Sorry can't accept cats.

4.86 out of 5 average rating, 577 reviews
Top guest favorite
A vibrant red tiny home features a modern metal roof and large glass doors for natural light. Windows on either side provide views of the surrounding landscape, while low-maintenance landscaping with gravel and small plants emphasizes the home’s rustic charm.
Tiny home in Espanola

The Barn - Tiny Home near Santa Fe & Los Alamos

About 30 minutes from Santa Fe, experience this awesome tiny home themed "The Barn"! The custom bathroom features a stock tank bathtub and sink that you can tell all of your friends and family about! The kitchen is furnished with a refrigerator/freezer, oven/stove, microwave, toaster, coffee pot and more. With a queen bed in the main space and a twin bed in the loft, The Barn can sleep up to 3 people. The home also has a smart TV and Wifi so you can enjoy your stay or catch up on work.

4.94 out of 5 average rating, 216 reviews
Guest favorite
The entrance to the adobe home is framed by a rugged stone wall, featuring steps that lead up to a wooden gate. Two large windows above showcase a triangular roof, complemented by a corrugated metal design.
Home in Ohkay Owingeh

Incredible Northern New Mexico Experience Awaits

Enjoy amazing vistas while you relax after a day hike, biking or rafting in the Rio Grande del Norte National Monument, or long day skiing. You'll love the memorable experience gained from this elegant adobe home. Prepare that savory dinner w/ amigos in the gourmet kitchen or enjoy a book during a soothing bath. The home kid friendly and centrally located w/ privacy you’ll cherish. Casa El Guiqueno provides the northern NM experience your looking for at a price that won’t break the bank.

4.93 out of 5 average rating, 122 reviews
Top guest favorite
An entrance to the property is framed by adobe walls with a decorative wooden arch and a carved detail. A path, lined with various plants and flowers, leads towards a set of red stairs surrounded by greenery and shade from the trees.
Apartment in Santa Fe

Studio in Santa Fe

Located 7 miles north of Santa Fe Plaza, this country retreat, is in the Village of Tesuque, one mile from Tesuque Village Market, El Nido Restaurant and Glenn Greene Galleries, five miles to the Santa Fe Opera, and 7 miles to the Santa Fe Plaza. Enjoy your own studio apartment with outdoor patio, private parking , in a peaceful country setting. Tesuque is central to many New Mexico experiences - visit nearby pueblos, state parks and monuments, casinos, rafting and hiking trails.

4.9 out of 5 average rating, 288 reviews
Top guest favorite
Cabin in Jemez Springs

River Oasis | Hot Springs Nearby

Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.

4.99 out of 5 average rating, 139 reviews
Guest favorite
The interior of the camper features a modern design with a spacious island in the center. Soft lighting is provided by decorative hanging lamps. A cozy seating area with a leather couch and two chairs is visible, complemented by natural light from large windows.
Camper/RV in Espanola

Charming Camper near Santa Fe

Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

4.94 out of 5 average rating, 217 reviews
Guest favorite
A living area showcases clay tile flooring with an area rug, featuring a comfortable sofa and a glass coffee table. A fireplace creates a focal point, while soft natural light filters through nearby windows. Rustic wood beams add character to the ceiling.
Home in Santa Fe

Casa Encantada, Charming Northern New Mexico Adobe

Welcome to Casa Encantada! This charming historic adobe casa is the perfect getaway for those seeking an enchanting break from the bustle of city living. Nestled in the country, 20 miles north of downtown Santa Fe in the historic village of Nambe, this home is ideally situated for excursions to the many beautiful sites Northern New Mexico has to offer. Make Casa Encantada your base camp as you explore Santa Fe and beyond, then come home to a unique and comforting retreat.

4.89 out of 5 average rating, 227 reviews

Popular amenities for La Mesilla vacation rentals