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Vacation rentals in La Mesilla

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Top-rated vacation rentals in La Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Santa Fe
4.98 out of 5 average rating, 182 reviews

Tres Pastores - Beautiful Tesuque Escape

Welcome to your home away from home! Peaceful, spacious, (2100 sqft) private home on secluded 5 acre compound in beautiful Tesuque. Conveniently located just 9 miles from downtown Santa Fe. This beautiful adobe home has two large bedrooms, two bathrooms, and a fully stocked open concept kitchen. The home exudes Santa Fe charm with vigas throughout, Saltillo tile, functional kiva fireplace, and ample windows for natural lighting. Private outdoor patio and access to breathtaking views from gazebo

Guest favorite
Guest suite in Santa Fe
4.94 out of 5 average rating, 401 reviews

Eco Mountain Home Close To Town by McDant LLC

Our place is in the mountains on the edge of town and National Forest, 1.5 miles from 10,000 Waves Japanese Spa, 10 minutes to the Plaza in the heart of Santa Fe, and 20 minutes to the ski basin with unlimited hiking and mountain biking in between. The house is tasteful, private, quiet, has amazing views, and has easy access to Santa Fe's finest restaurants, galleries, and activities. Great for couples, solo or family adventurers, or business travelers. 4X4 recommended in winter, check with us.

Top guest favorite
A spacious living area is highlighted by expansive sliding glass doors that connect to an outdoor patio. A casual seating area features a light-colored sofa and a round dining table set with a decorative centerpiece. Natural light floods the space, enhancing the earthy tones of the decor.
Home in Santa Fe
4.99 out of 5 average rating, 156 reviews

Happy Ram: Views! Beautiful. Peaceful. Upscale.

Want a unique, stylish, peaceful stay in Santa Fe? Happy Ram is an architect-designed, professionally decorated home on a 6.4-acre estate. Huge views of the Sangre de Cristo mountains from every room. Thick rammed earth walls create incredible quiet. Bedrooms on opposite sides of the home for maximum privacy. Patio with fireplace. Just 5 minutes to hip Tesuque Village, 6 to Four Seasons Resort, 11 to Santa Fe Opera, 14 to Santa Fe Plaza. Make your Santa Fe dream vacation come true! STRO-40172

Guest favorite
A series of images showcases the guest house and farm setting. The large bedroom features a king bed and natural light from a window. The farmhouse kitchen includes wooden cabinets and cooking utensils. The organic garden reveals rows of vegetables, while a chicken interacts with a simple nesting area.
Farm stay in Santa Fe
4.92 out of 5 average rating, 119 reviews

Nambé Farm Stay

Join us on our organic veggie farm, 20 minutes north of Santa Fe and 25 minutes from Los Alamos, in beautiful Nambé. Our guest house is a stand alone casita with a fenced-in yard for your dogs, on our 5 acre working-farm property. The space has a large bedroom with king bed and writing desk, a living room with a comfy leather couch, tv with streaming capacity, a large bathroom with a tub, shower, washer/dryer, and a farmhouse kitchen to cook in. There is WiFi through-out. Pop-up cot available.

Top guest favorite
A modern modular structure sits against a clear blue sky. The exterior features a striking dark facade with wooden accents. A spacious deck is adorned with two wooden chairs, inviting relaxation while offering views of the surrounding high desert landscape and distant mountains.
Home in El Prado
4.97 out of 5 average rating, 346 reviews

Taos Skybox "Horizons" High Desert Retreat

Set on 30 acres of private land on the western edge of town, Taos Skybox "Horizons" studio is a unique vacation home experience, purpose-built to take advantage of the dark skies and endless vistas of the high desert landscape. Sitting at 7,000 ft. above sea level, views abound, as your retreat borders Taos Pueblo Native lands, yet is only 15 minutes from the Taos Plaza. Truly a memorable destination, Horizons is modern and well-equipped with a full kitchen, laundry, and fiber optic internet!

Top guest favorite
Guest suite in Santa Fe
4.85 out of 5 average rating, 565 reviews

The Family Casita Santa Fe/ Pojoaque

The Family Casita is the guest wing to a family home with a private separate entrance. This is a large elegant adobe with thick walls that keep it cool in the summer and provide old world charm. A very spacious 900 square foot studio space, it has two original fireplaces, one in the eat-in kitchen, and one in the main room. There is a beautiful hand painted king sized bed and a Euro Lounger (that converts to a double bed), separated by a privacy wall. Dogs welcome. Sorry can't accept cats.

Top guest favorite
An open living area features wooden beams and large windows that invite natural light. A sofa and armchair are complemented by a decorative ottoman and a woven rug. A kitchen island with seating is present, enhancing the inviting space.
Home in Dixon
5 out of 5 average rating, 297 reviews

Stylish cottage in a beautiful canyon on the river

We welcome guests of all races, faiths, genders, sexual orientations, and countries of origin. Over a bridge and steps from the Embudo River, this stylish, well-equipped cottage is nestled under cottonwood trees in a private canyon facing a stunning rock face. Relax on the deck overlooking the water, and during late spring and early summer, listen to the river as you fall asleep. The quaint village of Dixon (an artist and vineyard, orchard, organic farm community) is just a mile away.

Top guest favorite
A hot tub is situated on a wooden deck, surrounded by tall trees and a clear blue sky. The water's surface reflects the sunlight, creating a serene setting for relaxation amidst a forest backdrop.
Cabin in Jemez Springs
4.94 out of 5 average rating, 209 reviews

Cozy Forest Escape with Private Hot Tub

Escape to a Peaceful Forest Retreat Nestled on a 1.5-acre wooded lot, this relaxing cabin offers the perfect retreat for nature lovers and adventure seekers. Located adjacent to the Valles Caldera National Preserve, our property boasts: - Relaxing Hot Tub: Unwind among the pines - Wildlife watching opportunities - Short drive to Fenton Lake for top-notch fishing - Modern comforts for a peaceful stay - Proximity to outdoor activities for all seasons: hiking, biking, fishing, and skiing

Top guest favorite
An authentic log cabin is positioned among natural landscaping, featuring a spacious deck with a red umbrella. A firepit area with red chairs is visible nearby, surrounded by stones and greenery. The mountains are softly illuminated by the evening sky, enhancing the tranquil setting.
Cabin in Jemez Springs
4.98 out of 5 average rating, 121 reviews

River Oasis | Hot Springs Nearby

Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.

Top guest favorite
An aerial view captures the adobe casita nestled among lush greenery, emphasizing its organic shape and earthy tones. Surrounding trees provide a natural setting, while the blue turquoise chairs offer a pop of color against the landscape, enhancing the tranquil atmosphere of the property.
Guesthouse in Santa Fe
4.97 out of 5 average rating, 190 reviews

Mary Ann's Mountain Retreat - Casita

Nestled up in the quiet Sangre de Cristo foothills in the sought after east side of Santa Fe, w breathtaking western views of the Jemez Mountains. 4 miles to the heart of town, 3 miles to Canyon Road, 1 mile to museum Hill. Just off of the historic Old Santa Fe Trail, up 3/10 of a mile up a private, maintained dirt road, in a rural gated community. Enter your cozy adobe, pristine casita. Ideal space for a romantic getaway, or solitary retreat. Across the porch from my Casa.

Guest favorite
Camper/RV in Española
4.94 out of 5 average rating, 204 reviews

Charming Camper near Santa Fe

Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

Guest favorite
Home in Santa Fe
4.88 out of 5 average rating, 224 reviews

Casa Encantada, Charming Northern New Mexico Adobe

Welcome to Casa Encantada! This charming historic adobe casa is the perfect getaway for those seeking an enchanting break from the bustle of city living. Nestled in the country, 20 miles north of downtown Santa Fe in the historic village of Nambe, this home is ideally situated for excursions to the many beautiful sites Northern New Mexico has to offer. Make Casa Encantada your base camp as you explore Santa Fe and beyond, then come home to a unique and comforting retreat.

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