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Vacation rentals in La Mesilla

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Top-rated vacation rentals in La Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A cozy sleeping area features a spacious bed adorned with fluffy white pillows and a light duvet, surrounded by large windows allowing natural light to illuminate the space. Two soft, circular poufs rest on a rug, contributing to the inviting atmosphere.
Cottage in Santa Fe
4.96 out of 5 average rating, 363 reviews

Sky-filled 'Studio Cielito' @ Rancho Los Sonadores

Welcome to Studio Cielito - a desert-inspired cottage designed with bath lovers in mind. Curated with vintage touches, luxury linens, and everything you need to relax and rejuvenate near the magical Sangre de Cristo Mountains. Just 8 mins from Meow Wolf and 14 mins from The Plaza, but surrounded by nature with a country feel. If your dates are not avail, click on our profile for our other rentals. **Due to COVID-19, we are asking that all guests be vaccinated to help keep our community safe.

Top guest favorite
A spacious living area is highlighted by expansive sliding glass doors that connect to an outdoor patio. A casual seating area features a light-colored sofa and a round dining table set with a decorative centerpiece. Natural light floods the space, enhancing the earthy tones of the decor.
Home in Santa Fe
4.99 out of 5 average rating, 156 reviews

Happy Ram: Views! Beautiful. Peaceful. Upscale.

Want a unique, stylish, peaceful stay in Santa Fe? Happy Ram is an architect-designed, professionally decorated home on a 6.4-acre estate. Huge views of the Sangre de Cristo mountains from every room. Thick rammed earth walls create incredible quiet. Bedrooms on opposite sides of the home for maximum privacy. Patio with fireplace. Just 5 minutes to hip Tesuque Village, 6 to Four Seasons Resort, 11 to Santa Fe Opera, 14 to Santa Fe Plaza. Make your Santa Fe dream vacation come true! STRO-40172

Top guest favorite
A modern structure features large glass panels that reflect the vibrant hues of a sunset. An outdoor deck is accented by a wooden lounge chair, inviting relaxation while enjoying the expansive views of the surrounding high desert landscape.
Home in El Prado
4.97 out of 5 average rating, 345 reviews

Taos Skybox "Horizons" High Desert Retreat

Set on 30 acres of private land on the western edge of town, Taos Skybox "Horizons" studio is a unique vacation home experience, purpose-built to take advantage of the dark skies and endless vistas of the high desert landscape. Sitting at 7,000 ft. above sea level, views abound, as your retreat borders Taos Pueblo Native lands, yet is only 15 minutes from the Taos Plaza. Truly a memorable destination, Horizons is modern and well-equipped with a full kitchen, laundry, and fiber optic internet!

Guest favorite
Cabin in Glorieta
4.9 out of 5 average rating, 151 reviews

Hilltop Nest

Kick back and relax in this stylish cabin in the forest. Hilltop location with forever views. Just off scenic Route 66 (Hwy 50), up a steep (but short) driveway, sits a 2-bedroom log cabin with plenty of birdsong and pine trees, a porch surrounded by views and furnished with a grill for outdoor dining. Five miles east is the village of Pecos with the Pecos River for fishing, hiking, and exploring. Sixteen miles north is the legendary city of Santa Fe packed with world-class art and culture

Top guest favorite
A hot tub is situated on a wooden deck, surrounded by tall trees and a clear blue sky. The water's surface reflects the sunlight, creating a serene setting for relaxation amidst a forest backdrop.
Cabin in Jemez Springs
4.94 out of 5 average rating, 208 reviews

Cozy Forest Escape with Private Hot Tub

Escape to a Peaceful Forest Retreat Nestled on a 1.5-acre wooded lot, this relaxing cabin offers the perfect retreat for nature lovers and adventure seekers. Located adjacent to the Valles Caldera National Preserve, our property boasts: - Relaxing Hot Tub: Unwind among the pines - Wildlife watching opportunities - Short drive to Fenton Lake for top-notch fishing - Modern comforts for a peaceful stay - Proximity to outdoor activities for all seasons: hiking, biking, fishing, and skiing

Guest favorite
Home in Abiquiu
4.81 out of 5 average rating, 541 reviews

Raven House

This cozy 2-story home sits on 10 acres in the Chama River Valley. A seasonal creek runs along edge of land with amazing mountain views. Ideal for a single artist, couple or small family. Hiking + hot springs nearby, including Ghost Ranch, Poshuouingue ruins & Ojo Caliente Springs! Most pets are welcome (for a pet fee). It's helpful to check in on it, however, due to our contained pups further back on the land. Open to longer stays at discounted price. Write about either to discuss!

Top guest favorite
Cabin in Jemez Springs
4.98 out of 5 average rating, 120 reviews

River Oasis | Hot Springs Nearby

Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.

Top guest favorite
An aerial view captures the adobe casita nestled among lush greenery, emphasizing its organic shape and earthy tones. Surrounding trees provide a natural setting, while the blue turquoise chairs offer a pop of color against the landscape, enhancing the tranquil atmosphere of the property.
Guesthouse in Santa Fe
4.97 out of 5 average rating, 190 reviews

Mary Ann's Mountain Retreat - Casita

Nestled up in the quiet Sangre de Cristo foothills in the sought after east side of Santa Fe, w breathtaking western views of the Jemez Mountains. 4 miles to the heart of town, 3 miles to Canyon Road, 1 mile to museum Hill. Just off of the historic Old Santa Fe Trail, up 3/10 of a mile up a private, maintained dirt road, in a rural gated community. Enter your cozy adobe, pristine casita. Ideal space for a romantic getaway, or solitary retreat. Across the porch from my Casa.

Guest favorite
Camper/RV in Española
4.94 out of 5 average rating, 204 reviews

Charming Camper near Santa Fe

Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

Guest favorite
Home in Santa Fe
4.88 out of 5 average rating, 224 reviews

Casa Encantada, Charming Northern New Mexico Adobe

Welcome to Casa Encantada! This charming historic adobe casa is the perfect getaway for those seeking an enchanting break from the bustle of city living. Nestled in the country, 20 miles north of downtown Santa Fe in the historic village of Nambe, this home is ideally situated for excursions to the many beautiful sites Northern New Mexico has to offer. Make Casa Encantada your base camp as you explore Santa Fe and beyond, then come home to a unique and comforting retreat.

Top guest favorite
The entrance of a rustic casita is framed by a tree, featuring a shaded porch with a small table and two chairs. A potted plant adds a touch of greenery. The door is flanked by wall sconces, and a welcoming bell hangs above.
Guesthouse in Santa Fe
4.97 out of 5 average rating, 671 reviews

Beautiful View

Nambé, New Mexico in Santa Fe County quiet rural setting. It is located 20 minutes from Historic Santa Fe, surrounded by Ancient Anasazi hiking trails and ruins. On the High Road to Taos. Enjoy the peace of the country. Safe and friendly. Romantic, comfortable ,within a private compound. All the amenities of home. Star filled nights, quaint, beautiful accommodations and a charming shared garden to relax and enjoy the beauty of the view of the Sangre de Cristo Mountains.

Top guest favorite
A single-story casita showcases a neutral adobe exterior with large windows. A covered porch is highlighted, featuring a wooden railing and steps leading to the grassy area. The bright blue sky complements the warm tones of the structure.
Home in Santa Fe
4.99 out of 5 average rating, 354 reviews

Sunrise Casita

Come home to peace and tranquility conveniently located just ten minutes south of Santa Fe in the La Cienega Valley. Experience the beautiful views, expansive night skies, and magnificent sunsets, from this comfortable, cozy, impeccably clean, one bedroom casita. There’s a wonderful porch in front to enjoy your morning cup of coffee. Whether a romantic getaway for two, or a serine retreat for one, you are certain to be enchanted.

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