Vacation rentals in La Mesilla

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Top-rated vacation rentals in La Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A cozy sleeping area features a spacious bed adorned with fluffy white pillows and a light duvet, surrounded by large windows allowing natural light to illuminate the space. Two soft, circular poufs rest on a rug, contributing to the inviting atmosphere.
Cottage in Santa Fe
4.97 out of 5 average rating, 374 reviews

Sky-filled “Studio Cielito” @ Rancho Los Sonadores

Welcome to Studio Cielito - a desert-inspired cottage designed with bath lovers in mind. Curated with vintage touches, luxury linens, and everything you need to relax and rejuvenate near the magical Sangre de Cristo Mountains. Just 8 mins from Meow Wolf and 14 mins from The Plaza, but surrounded by nature with a country feel. If your dates are not avail, click on our profile for our other rentals. **Due to COVID-19, we are asking that all guests be vaccinated to help keep our community safe.

Guest favorite
Guesthouse in Santa Fe
4.81 out of 5 average rating, 129 reviews

Desert Hideaway - Private Casita Suite

Brand new shower!! Experience the ultimate desert escape at our guest suite, nestled amidst majestic mountains. This charming oasis offers a serene retreat with a queen bed, full kitchen, bath, and dining room. Embrace the tranquility of the desert landscape as you relax in the cozy suite & savor panoramic mountain views. Immerse yourself in nature's beauty embarking on thrilling adventures. Discover the perfect balance between comfort & breathtaking surroundings in this idyllic desert haven.

Top guest favorite
A charming adobe casita is set against a serene backdrop, featuring warm lighting from windows. A shaded porch with wooden chairs overlooks the surrounding landscape. Natural desert plants frame the exterior, and a patio umbrella provides additional shade for outdoor relaxation.
Guesthouse in Abiquiu
4.97 out of 5 average rating, 118 reviews

Viento del Rio - Abiquiu Casita W/Private Hot Tub

Viento del Rio is a perfect place to absorb the serenity of the Abiquiu area. Located off the beaten path (but not too far) centrally located to many area wonders. There are numerous places to hike nearby. Views of mountains (including Pedernal) in all directions are stunning. Nearby attractions include Plaza Blanca, Georgia O'Keefe Welcome Center and Ghost Ranch. Easy drive to Taos and Santa Fe. A truly lovely place to rest, relax and take in all the nearby sites and activities.

Top guest favorite
Cabin in Jemez Springs
4.99 out of 5 average rating, 136 reviews

River Oasis | Hot Springs Nearby

Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.

Guest favorite
The interior of the camper features a modern design with a spacious island in the center. Soft lighting is provided by decorative hanging lamps. A cozy seating area with a leather couch and two chairs is visible, complemented by natural light from large windows.
Camper/RV in Espanola
4.94 out of 5 average rating, 212 reviews

Charming Camper near Santa Fe

Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

Top guest favorite
The entrance of a rustic casita is framed by a tree, featuring a shaded porch with a small table and two chairs. A potted plant adds a touch of greenery. The door is flanked by wall sconces, and a welcoming bell hangs above.
Guesthouse in Santa Fe
4.97 out of 5 average rating, 697 reviews

Bonita Vista

Nambé, New Mexico in Santa Fe County quiet rural setting. It is located 20 minutes from Historic Santa Fe, surrounded by Ancient Anasazi hiking trails and ruins. On the High Road to Taos. Enjoy the peace of the country. Safe and friendly. Romantic, comfortable ,within a private compound. All the amenities of home. Star filled nights, quaint, beautiful accommodations and a charming shared garden to relax and enjoy the beauty of the view of the Sangre de Cristo Mountains.

Guest favorite
The kitchen features wooden cabinets and a spacious layout, equipped with a full-size refrigerator, electric stove, microwave, and a farmhouse-style sink. A dining table with four chairs is positioned centrally, with natural light illuminating the space from overhead fixtures.
Guesthouse in Espanola
4.96 out of 5 average rating, 91 reviews

Centrally Located Southwest Oasis-Sage Casita

Come soak up the sun and unwind in the Southwest. Sage Casita is peaceful, romantic and has lots of amenities. This casita is less than 30 minutes away from Santa Fe and Los Alamos. As well as less than 15 minutes from Espanola. Besides being centrally located, the casita is thoughtfully furnished making it the perfect place to stay in New Mexico. So come, reconnect with the wide open spaces of the Southwest and enjoy the taste of a peaceful oasis just outside of Santa Fe.

Superhost
Home in Espanola
4.57 out of 5 average rating, 7 reviews

Modern Dome Home near Santa Fe | Los Alamos | Taos

Escape to this newly renovated 3BR/2BA mountain retreat! Set on a private 1/3 acre near the Rio Grande, enjoy a fenced yard, vast outdoor space, and a cozy wood-fired stove. High-speed WiFi included. Prime location: next to Starbucks/Walmart, 30 mins to Santa Fe, and <1 hour to Taos skiing. Whether you're hiking, skiing, or relaxing, this stylish home offers the perfect blend of modern comfort and Northern NM charm. Book your high-desert stay today!

Top guest favorite
The cabin exterior presents a wooden structure with large windows framed in white, allowing for abundant natural light. A green metal roof contrasts with the wood finish. A gravel pathway leads to the front door, surrounded by a simple outdoor landscape.
Tiny home in Espanola
4.95 out of 5 average rating, 235 reviews

The Cabin - Tiny Home near Santa Fe & Los Alamos

Plan your vacation at this cute little cabin! The kitchen is furnished with a refrigerator/freezer, oven/stove, microwave, toaster, coffee pot and more. There is A/C and heating as well as a smart TV and Wifi so you can have a comfortable, relaxing, and productive stay! On top of all that, we are centrally located between Los Alamos, Santa Fe, Pojoaque and Taos so you can easily visit some of our most amazing tourist spots!

Top guest favorite
The interior of the casita features a king-sized bed with stylish bedding and a large artwork of a horse mounted above it. Two brown lounge chairs are positioned in the foreground, accompanied by a small table. Earthy tones and wooden beams contribute to a cozy atmosphere.
Home in Ojo Caliente
4.95 out of 5 average rating, 103 reviews

Luxury Desert Casita • Chiminea Nights • Views

Stay in a serene casita surrounded by the inspiring landscapes that shaped Georgia O’Keeffe’s art. Located just south of Ojo Caliente and a short drive from Ghost Ranch, this retreat offers effortless access to the area’s best hiking, hot springs, and high-desert beauty. With Ojo Mineral Springs only 14 miles away and dining within walking distance, it’s the perfect base for couples seeking both exploration and relaxation.

Guest favorite
A spacious bedroom is framed by wooden beams along the ceiling. A large bed, adorned with a blue blanket and decorative pillows, occupies the center. Colorful artwork hangs above the bed, and small windows allow natural light to fill the room.
Guesthouse in Espanola
4.91 out of 5 average rating, 112 reviews

Guest House in Espanola

This unique place has a style all its own. It is an adorable adobe casita with its own full bath, King bed, mini fridge, microwave and coffee maker. Located in the beautiful Espanola Valley, just 45 miles away from Taos, 25 miles away from Santa Fe and 17 miles away from Los Alamos.The Casita is located near local restaurants and shopping areas but is hidden in its own private beautiful neighborhood.

Guest favorite
Farm stay in Santa Fe
4.93 out of 5 average rating, 41 reviews

Finca del Sol - New Mexican Farm Casa

Beautifully restored 4BR/2.5BA farm casa just outside Santa Fe. Enjoy farm-fresh eggs, seasonal produce, and meet goats, sheep, chickens & ducks. Relax in the TV room, work with Starlink internet, or train in the covered outdoor gym. Picnic beneath old cottonwoods, stargaze by night, and take in stunning views of Ski Santa Fe, the Pojoaque Badlands & Jemez Mountains. Gateway to Northern NM adventures!

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