Vacation rentals in La Mesilla

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Top-rated vacation rentals in La Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A cozy sleeping area features a spacious bed adorned with fluffy white pillows and a light duvet, surrounded by large windows allowing natural light to illuminate the space. Two soft, circular poufs rest on a rug, contributing to the inviting atmosphere.
Cottage in Santa Fe
4.97 out of 5 average rating, 375 reviews

Sky-filled “Studio Cielito” @ Rancho Los Sonadores

Welcome to Studio Cielito - a desert-inspired cottage designed with bath lovers in mind. Curated with vintage touches, luxury linens, and everything you need to relax and rejuvenate near the magical Sangre de Cristo Mountains. Just 8 mins from Meow Wolf and 14 mins from The Plaza, but surrounded by nature with a country feel. If your dates are not avail, click on our profile for our other rentals. **Due to COVID-19, we are asking that all guests be vaccinated to help keep our community safe.

Top guest favorite
Cabin in Jemez Springs
4.99 out of 5 average rating, 139 reviews

River Oasis | Hot Springs Nearby

Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.

Guest favorite
The interior of the camper features a modern design with a spacious island in the center. Soft lighting is provided by decorative hanging lamps. A cozy seating area with a leather couch and two chairs is visible, complemented by natural light from large windows.
Camper/RV in Espanola
4.94 out of 5 average rating, 213 reviews

Charming Camper near Santa Fe

Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

Guest favorite
A spacious living area is characterized by high, exposed beam ceilings and large windows allowing natural light. Comfortable seating is arranged around a central table, with a cozy fireplace flanked by decorative elements. Textiles and artwork add warmth to the inviting space.
Guesthouse in Santa Fe
4.93 out of 5 average rating, 194 reviews

Stunning Creekside Hideaway with Hot Tub

In the heart of Santa Fe lies a beautiful home full of character and life. This home is great for a romantic couples retreat, peaceful getaway, ski trip or hiking adventure. Steps away from the start of the Windsor Trail, this amazing Santa Fe home includes an area for barbecuing, an amazing ridge with a 360° view and a home that will make you feel like you are at a resort. This oasis located in the hills of Santa Fe is everything you are looking for in a vacation getaway.

Top guest favorite
The entrance of a rustic casita is framed by a tree, featuring a shaded porch with a small table and two chairs. A potted plant adds a touch of greenery. The door is flanked by wall sconces, and a welcoming bell hangs above.
Guesthouse in Santa Fe
4.97 out of 5 average rating, 698 reviews

Bonita Vista

Nambé, New Mexico in Santa Fe County quiet rural setting. It is located 20 minutes from Historic Santa Fe, surrounded by Ancient Anasazi hiking trails and ruins. On the High Road to Taos. Enjoy the peace of the country. Safe and friendly. Romantic, comfortable ,within a private compound. All the amenities of home. Star filled nights, quaint, beautiful accommodations and a charming shared garden to relax and enjoy the beauty of the view of the Sangre de Cristo Mountains.

Top guest favorite
An aerial view captures the winding Chama River bordered by vibrant autumn trees, with rolling hills and rugged terrain extending into the distance. The red structure of the casita is visible along a dirt path, showcasing the serene landscape of Abiquiu.
Home in Abiquiu
4.91 out of 5 average rating, 333 reviews

Casa Granada, Sunny casita along on the Rio Chama

A tranquil experience and secluded getaway, yet easily accessible below the stunning Cerrito Blanco in Abiquiu. This 800 square foot casita makes the perfect weekend or week-long getaway for a couple or small family looking for a unique experience in beautiful Abiquiu. Sip your coffee outside or along the river, practice yoga, meditate, read, write, stargaze, bird watch and take in the beauty of the Chama River Valley, right in the heart of Tewa country!

Superhost
Home in Espanola
4.57 out of 5 average rating, 7 reviews

Modern Dome Home near Santa Fe | Los Alamos | Taos

Escape to this newly renovated 3BR/2BA mountain retreat! Set on a private 1/3 acre near the Rio Grande, enjoy a fenced yard, vast outdoor space, and a cozy wood-fired stove. High-speed WiFi included. Prime location: next to Starbucks/Walmart, 30 mins to Santa Fe, and <1 hour to Taos skiing. Whether you're hiking, skiing, or relaxing, this stylish home offers the perfect blend of modern comfort and Northern NM charm. Book your high-desert stay today!

Top guest favorite
The cabin exterior presents a wooden structure with large windows framed in white, allowing for abundant natural light. A green metal roof contrasts with the wood finish. A gravel pathway leads to the front door, surrounded by a simple outdoor landscape.
Tiny home in Espanola
4.95 out of 5 average rating, 236 reviews

The Cabin - Tiny Home near Santa Fe & Los Alamos

Plan your vacation at this cute little cabin! The kitchen is furnished with a refrigerator/freezer, oven/stove, microwave, toaster, coffee pot and more. There is A/C and heating as well as a smart TV and Wifi so you can have a comfortable, relaxing, and productive stay! On top of all that, we are centrally located between Los Alamos, Santa Fe, Pojoaque and Taos so you can easily visit some of our most amazing tourist spots!

Top guest favorite
The interior of the casita features a king-sized bed with stylish bedding and a large artwork of a horse mounted above it. Two brown lounge chairs are positioned in the foreground, accompanied by a small table. Earthy tones and wooden beams contribute to a cozy atmosphere.
Home in Ojo Caliente
4.95 out of 5 average rating, 103 reviews

Luxury Desert Casita • Chiminea Nights • Views

Stay in a serene casita surrounded by the inspiring landscapes that shaped Georgia O’Keeffe’s art. Located just south of Ojo Caliente and a short drive from Ghost Ranch, this retreat offers effortless access to the area’s best hiking, hot springs, and high-desert beauty. With Ojo Mineral Springs only 14 miles away and dining within walking distance, it’s the perfect base for couples seeking both exploration and relaxation.

Guest favorite
Tiny home in Espanola
5.0 out of 5 average rating, 10 reviews

Casita Viernes

A newly built casita in a convenient central location, provides easy access to Santa Fe, Los Alamos, Espanola, Abiquiu and Taos. Close to many special attractions such as Santuario de Chimayo, Puye Cliff dwellings, Bandelier National Monument, Los Alamos, Espanola Valley Fiber Arts Center and much more. We are only a few minutes drive off of route 285 in a quiet neighborhood situated behind the Dreamcatcher movie theater.

Guest favorite
A spacious bedroom is framed by wooden beams along the ceiling. A large bed, adorned with a blue blanket and decorative pillows, occupies the center. Colorful artwork hangs above the bed, and small windows allow natural light to fill the room.
Guesthouse in Espanola
4.91 out of 5 average rating, 113 reviews

Guest House in Espanola

This unique place has a style all its own. It is an adorable adobe casita with its own full bath, King bed, mini fridge, microwave and coffee maker. Located in the beautiful Espanola Valley, just 45 miles away from Taos, 25 miles away from Santa Fe and 17 miles away from Los Alamos.The Casita is located near local restaurants and shopping areas but is hidden in its own private beautiful neighborhood.

Guest favorite
Farm stay in Santa Fe
4.93 out of 5 average rating, 41 reviews

Finca del Sol - New Mexican Farm Casa

Beautifully restored 4BR/2.5BA farm casa just outside Santa Fe. Enjoy farm-fresh eggs, seasonal produce, and meet goats, sheep, chickens & ducks. Relax in the TV room, work with Starlink internet, or train in the covered outdoor gym. Picnic beneath old cottonwoods, stargaze by night, and take in stunning views of Ski Santa Fe, the Pojoaque Badlands & Jemez Mountains. Gateway to Northern NM adventures!

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