Vacation rentals in De Soto

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in De Soto

Guests agree: these stays are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1

Top guest favorite

The kitchen features classic wooden cabinetry and retro-style appliances, including a pale cream refrigerator. A patterned backsplash complements the checkered floor, while shelves display colorful dinnerware. Natural light fills the space, enhancing the inviting atmosphere for cooking and gathering.

Home in Ankeny

Historic Home on 4 Acres - Hot Tub, Pool, Tiki Bar

Our 1948 vacation home is on 4 acres & boasts 3 bedrooms, 3 full baths, 2 half baths, Bridal Suite (4th bedroom), 70s TV/Game Room, Tiki Bar, & Children's Playroom. Outside we have a pool (guaranteed to be open 5/26 - 9/5) & hot tub (year round). Located 15min away from Downtown DSM & a mile away from a grocery store/restaurants. Up to 2 dogs allowed for an additional fee. ***Events/photo shoots are allowed with written permission only and will be an added fee. No events larger than 25 total.***

4.97 out of 5 average rating, 210 reviews

Top guest favorite

A treehouse, elevated on stilts, is surrounded by various trees and greenery. The wooden structure features large windows and a balcony, with a staircase leading up, inviting guests to its elevated entrance. Bright blue skies provide a clear backdrop.

Treehouse in Norwalk

RARE Spacious Treehouse & Sauna Near Des Moines

Come home to luxury in nature in this spacious, double king-bed treehouse and sleep among the stars. Expansive views of rolling hills greet you as you sip your pour-over coffee on the wrap around balcony twenty feet above ground. Rain? No problem. Tuck away on the three-season screened-in porch to watch the iconic Iowa pink sunsets. Built with special touches including stained glass and intricate woodwork, this treehouse boasts warmth throughout and is sure to be a once-in-a-lifetime get-away.

5.0 out of 5 average rating, 102 reviews

Top guest favorite

A clear blue swimming pool is framed by a spacious wooden deck. Umbrellas in red and blue provide shade for the nearby seating areas. The house is visible in the background, featuring large windows that open to the outdoor space.

Home in Urbandale

Big Groups/Pool/Hot tub/Large backyard/Fire Pit

Gather your group in this spacious 5BR, 3BA retreat made for connection and fun. After a day exploring, come back to the pool, hot tub, and sunroom dining. Inside, unwind in two cozy lounges or spark friendly competition in the arcade and game-filled garage. With room for 16, this home isn’t just a stay—it’s where family and friends celebrate, play, and make lasting memories together. Close to: 🏴󠁴5 mins to Get Air Trampoline Park ⛳ 10 minutes to Topgolf 🌆 20 minutes to Downtown Des Moines

4.97 out of 5 average rating, 131 reviews

Top guest favorite

Home in Clive

Modern Functional 5BR 3BA Ranch Home In Clive

This home offers blend of comfort cozy and functionality. Modern crafted ranch style offering over 3,500 square feet of luxury functionality and more. This home has 5 bedrooms 3 full baths 10’ ceilings spacious mudroom/laundry gourmet kitchen with a spacious island. Lower level has a large family room a bar area pool table/ping pong table table board games. Access to outdoor BBQ area with stairs leading to upper closed in deck. Basketball hoop Park on driveway garage & opposite side of street

5.0 out of 5 average rating, 44 reviews

Top guest favorite

A high wooden ceiling features exposed beams, creating a rustic atmosphere. A railing offers a view down to a living area with a neutral color palette, where a fireplace and decorative elements can be seen in the background.

Cottage in Redfield

Raccoon River Retreats

Come & experience the magic of this unique getaway,where the warmth of a renovated 1900's home meets the natural wonders of the Raccoon River. 30min from DSM,Ia.Whether you enjoy an adventure on the river of kayaking, paddle boarding, fishing,a peaceful moment along the biking trails,cozy up with a cup of coffee by the fireplace or a fire in the outdoor fire pit,our retreat has an idyllic setting to create lasting memories.A scenic landmark, local restaurant,Dairy shop & Dollar General are near

4.99 out of 5 average rating, 136 reviews

Top guest favorite

A cozy living room features a modern fireplace framed by white cabinetry and shelves displaying decorative items. A flat-screen TV is mounted on the wall. Comfortable seating includes a dark armchair and a tan sofa, with a light area rug covering the hardwood floor.

Home in Waukee

Bring the family or group of friends to this spacious 4bdrm, 3ba home. Enjoy the king suite, complete with an ensuite bath which includes a relaxing Jacuzzi Tub! Cook your favorite meals in the fully stocked kitchen. Pack light & utilize the W/D. Enjoy outdoor fun in the fenced in yard. Located in a family-friendly neighborhood. Located close to local restaurants and parks. Whether you're here for a weekend away or an extended stay, this retreat offers everything you need for a memorable stay.

5.0 out of 5 average rating, 75 reviews

Top guest favorite

A modern living room features a comfortable gray sofa and two brown accent chairs beside a stylish coffee table. A flat-screen TV is mounted above a sleek fireplace, with shelving displaying decorative items. Natural light filters in through the large windows, creating an inviting ambiance.

Home in Waukee

Waukee Guest House - Close to everything in DSM

Welcome to the Waukee Guest House! You will love calling this new, expanded ranch-style home your central Iowa home away from home. Located just minutes from I-80, our house is a 10-minute drive from Jordan Creek Mall in West Des Moines and 15 min. from downtown Des Moines and Wells Fargo Arena. You can access 4 bedrooms, 3 full baths, a large kitchen/dining area, and two beautiful living room spaces during your stay. We offer Smart TVs in every bedroom and living room space.

4.99 out of 5 average rating, 142 reviews

Top guest favorite

A spacious living area features a modern design with a large sofa and two green accent chairs. A sleek entertainment unit with a fireplace is centered on the wall. Large windows provide natural light, enhancing the open and airy atmosphere.

Barn in Des Moines

8000sqft Barndo | Indoor Court + 2 Living Qtrs

Welcome to The Lodge on 3rd - a massive 8000 sq ft Barndominum. Nestled in the heart of Des Moines, Iowa, this stunning retreat offers the perfect blend of rustic charm and modern elegance. With 4 spacious bedrooms and a large loft, there is plenty of room for you and your guests to unwind in style. This property is next door to Luxury Living on Third. airbnb.com/h/luxurylivingonthird These combined properties are ideal for family reunions, etc. ***$200 Pet Fee***

5.0 out of 5 average rating, 174 reviews

Guest favorite

The two-story farmhouse features a white exterior and a welcoming front porch, adorned with potted plants. A staircase leads to the entrance, flanked by a neat lawn. An American flag is displayed, adding to the home's charm and character.

Home in Earlham

Friendly Quarters

This charming location is a farmhouse style home built in 1914. Easily found on the main street through town, a one block walk in any given direction will put you at the center of the city. A grocery story, eating establishments, gift shops and community center are conveniently located in the downtown area. Friendly Quarters operates as a non-profit organization to support the missions and ministries of Earlham Friends (Quaker) Church located right next door.

4.95 out of 5 average rating, 142 reviews

Top guest favorite

An open-plan living area is shown, featuring a comfortable gray sofa with orange pillows. A wooden dining table is accompanied by black chairs, while a ceiling fan adds to the airiness. Sliding barn doors lead to another room, and natural light enhances the inviting feel.

Home in Winterset

The Roost at Speckled Hen Farms.

Explore the Iowa countryside with this 70's ranch as your relaxing base camp. Situated on 5 acres of rolling hills in rural Madison County, Iowa, this centrally located homestead has something for every kind of traveler. The charming town of Winterset is just minutes away, as well the historic Covered Bridges, wineries, breweries, parks and more. Located next to Speckled Hen Farms farm store and Lone Oaks Farm, you can take in an occasional music event or class!

5.0 out of 5 average rating, 100 reviews

Guest favorite

A two-story house is shown with a modern blue exterior featuring light stone accents. A spacious driveway leads to a two-car garage, with manicured grass in the foreground. A sunset creates a warm glow behind the home, enhancing the peaceful setting.

Home in Van Meter

New Build w/ Fab design! Theater/Game Sleeps 12!

Brand-new 4BR/3BA home with 2,300 sq ft of open, modern living space just outside West Des Moines. Perfect for families, groups, reunions, and retreats. ✔ 100" home theater + soundbar ✔ Fully loaded game room ✔ Designer open-concept layout ✔ Backyard with pond views & sunsets ✔ Quiet neighborhood | Quick I-80 access ✔ 15 min to Jordan Creek | 12 to RecPlex | 20 to Downtown Des Moines High-speed WiFi. Sleeps 10

4.91 out of 5 average rating, 23 reviews

Superhost

Home in Adel

The Cottage on Prairie Street

Pet friendly. Stay steps from Adel’s historic town square in this charming 1937 cottage! Walk to local shops, cafes, and restaurants. Enjoy a fenced yard, fully stocked kitchen, washer/dryer, and no pet fees. Perfect for couples, families, and guests visiting or exploring central Iowa. The Cottage is just a quick drive to Waukee, West Des Moines, Winterset, and more.

4.76 out of 5 average rating, 50 reviews