Vacation rentals in De Soto

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in De Soto

Guests agree: these stays are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1
Top guest favorite
The kitchen features classic wooden cabinetry and retro-style appliances, including a pale cream refrigerator. A patterned backsplash complements the checkered floor, while shelves display colorful dinnerware. Natural light fills the space, enhancing the inviting atmosphere for cooking and gathering.
Home in Ankeny

Historic Home on 4 Acres - Hot Tub, Pool, Tiki Bar

Our 1948 vacation home is on 4 acres & boasts 3 bedrooms, 3 full baths, 2 half baths, Bridal Suite (4th bedroom), 70s TV/Game Room, Tiki Bar, & Children's Playroom. Outside we have a pool (guaranteed to be open 5/26 - 9/5) & hot tub (year round). Located 15min away from Downtown DSM & a mile away from a grocery store/restaurants. Up to 2 dogs allowed for an additional fee. ***Events/photo shoots are allowed with written permission only and will be an added fee. No events larger than 25 total.***

4.97 out of 5 average rating, 212 reviews
Guest favorite
A treehouse, elevated on stilts, is surrounded by various trees and greenery. The wooden structure features large windows and a balcony, with a staircase leading up, inviting guests to its elevated entrance. Bright blue skies provide a clear backdrop.
Treehouse in Norwalk

RARE Spacious Treehouse & Sauna Near Des Moines

Come home to luxury in nature in this spacious, double king-bed treehouse and sleep among the stars. Expansive views of rolling hills greet you as you sip your pour-over coffee on the wrap around balcony twenty feet above ground. Rain? No problem. Tuck away on the three-season screened-in porch to watch the iconic Iowa pink sunsets. Built with special touches including stained glass and intricate woodwork, this treehouse boasts warmth throughout and is sure to be a once-in-a-lifetime get-away.

4.99 out of 5 average rating, 105 reviews
Top guest favorite
Home in Clive

Modern Functional 5BR 3BA Ranch Home In Clive

This home offers blend of comfort cozy and functionality. Modern crafted ranch style offering over 3,500 square feet of luxury functionality and more. This home has 5 bedrooms 3 full baths 10’ ceilings spacious mudroom/laundry gourmet kitchen with a spacious island. Lower level has a large family room a bar area pool table/ping pong table table board games. Access to outdoor BBQ area with stairs leading to upper closed in deck. Basketball hoop Park on driveway garage & opposite side of street

5.0 out of 5 average rating, 46 reviews
Guest favorite
A spacious living area features large windows that allow natural light to fill the room and provide views of the surrounding landscape. Comfortable seating options include plush sofas and bean bags arranged around a decorative coffee table on a patterned rug. A flat-screen TV is positioned near a stone fireplace.
Cabin in Norwalk

Private lake, lodge & 23 acres south of Des Moines

Amazing, secluded 23 acres of property highlighted with a 6 BR lodge and your own PRIVATE lake. For the bike enthusiast, the famous 17 mile Great Western bike trail is located right at the driveway. For the kids or kid-at-heart, enjoy numerous activities & games: - basketball court - sand VB court - 6 kayaks - 2 ping pong tables - billiards table - air hockey - 2 foosball tables - numerous board & card games - ladder ball, bag toss Located <15 miles south of Des Moines/Jordan Creek Mall.

4.95 out of 5 average rating, 102 reviews
Top guest favorite
A high wooden ceiling features exposed beams, creating a rustic atmosphere. A railing offers a view down to a living area with a neutral color palette, where a fireplace and decorative elements can be seen in the background.
Cottage in Redfield

Raccoon River Retreats

Come & experience the magic of this unique getaway,where the warmth of a renovated 1900's home meets the natural wonders of the Raccoon River. 30min from DSM,Ia.Whether you enjoy an adventure on the river of kayaking, paddle boarding, fishing,a peaceful moment along the biking trails,cozy up with a cup of coffee by the fireplace or a fire in the outdoor fire pit,our retreat has an idyllic setting to create lasting memories.A scenic landmark, local restaurant,Dairy shop & Dollar General are near

4.99 out of 5 average rating, 139 reviews
Top guest favorite
A comfortable living area features a large smart television on a wooden console, complemented by a stylish area rug. Indoor plants are positioned near the sliding glass doors, which provide natural light and a view of the outdoor deck. A decorative lamp and wall clock enhance the space.
Guest suite in Waukee

Waukee 2 Bedroom Private Sweet Suite.

Welcome to our comfortable, newly renovated, private guest suite. This quiet Waukee neighborhood living space includes two bedrooms, one full bath, kitchenette, laundry room, dining space and cozy living room area. Off street parking for one vehicle is available. A private entrance is available from the back deck. Your home away from home features a comfortable king size bed and a full size bed. A smart television is available in the living room and an HDTV is available in one bedroom.

4.99 out of 5 average rating, 357 reviews
Top guest favorite
A paved pathway leads through a lush green lawn, framed by a variety of trees. In the distance, a timber frame lodge is visible, surrounded by landscaped gardens and a backdrop of colorful autumn foliage.
Home in Adel

Timberpine Lodge - Escape to the Country

Escape to a stunning Iowa rural landscape and enjoy a peaceful getaway at this fantastic vacation rental. Hosting 4 bedrooms, 3.5 baths, and a well-appointed living space with a log-cabin feel, this home invites you to unwind with ease after days spent venturing down Raccoon River waters or cycling the Raccoon River Bike Trail. The lodge is an authentic timber frame structure. Step outside and listen to the breeze pass through trees, the chirps of seasonal birds, and calls of other wildlife.

4.99 out of 5 average rating, 70 reviews
Guest favorite
Home in Van Meter

Designer 4BR-New Build! Giant TV, Great for Groups

This newly built Van Meter home offers 4.5 bedrooms, 3 bathrooms, and space for up to 10 guests — ideal for family travel, group getaways, sports teams, and corporate retreats. Private home theater with 86" screen, 50" Smart TVs in every bedroom, modern finishes, and a deck with stunning pond and sunset views. Minutes from I-80, Jordan Creek Mall, RecPlex, Downtown Des Moines, Winterset, Adel, and Waukee. Quiet, safe neighborhood — new build means no wear, just clean comfort!

5.0 out of 5 average rating, 10 reviews
Guest favorite
The two-story farmhouse features a white exterior and a welcoming front porch, adorned with potted plants. A staircase leads to the entrance, flanked by a neat lawn. An American flag is displayed, adding to the home's charm and character.
Home in Earlham

Friendly Quarters

This charming location is a farmhouse style home built in 1914. Easily found on the main street through town, a one block walk in any given direction will put you at the center of the city. A grocery story, eating establishments, gift shops and community center are conveniently located in the downtown area. Friendly Quarters operates as a non-profit organization to support the missions and ministries of Earlham Friends (Quaker) Church located right next door.

4.95 out of 5 average rating, 142 reviews
Top guest favorite
An open-plan living area is shown, featuring a comfortable gray sofa with orange pillows. A wooden dining table is accompanied by black chairs, while a ceiling fan adds to the airiness. Sliding barn doors lead to another room, and natural light enhances the inviting feel.
Home in Winterset

The Roost at Speckled Hen Farms.

Explore the Iowa countryside with this 70's ranch as your relaxing base camp. Situated on 5 acres of rolling hills in rural Madison County, Iowa, this centrally located homestead has something for every kind of traveler. The charming town of Winterset is just minutes away, as well the historic Covered Bridges, wineries, breweries, parks and more. Located next to Speckled Hen Farms farm store and Lone Oaks Farm, you can take in an occasional music event or class!

5.0 out of 5 average rating, 100 reviews
Guest favorite
A view of a charming farmhouse surrounded by vibrant pink flowers in full bloom. A white picket fence lines the flowerbed, while the house sits peacefully amidst a backdrop of lush greenery and clear blue skies.
Farm stay in Winterset

Entire farmhouse in the country

Just 10 minutes north of Winterset, stay in a Covered Bridge House. You’ll love visiting the historic bridges & John Wayne Birthplace Museum. Perfect for families and groups, enjoy relaxing at our newly renovated “modern farmhouse style” home. A quiet retreat, nestled in beautiful rolling hills. Built by Eli Cox family, renowned covered bridge builders. It’s a short 5 minute drive to local attractions: Winterset Cidery, Covered Bridges Winery & Guye Woods.

4.98 out of 5 average rating, 62 reviews
Top guest favorite
A charming two-story house is situated on a spacious lawn, featuring a sloped roof with a dark finish. The front porch is flanked by two large windows, and a paved walkway leads to the entrance. A rural landscape with trees is visible in the background.
Home in Minburn

Cheerful 3 bedroom home in a quiet small town

Come relax with your family in this peaceful and stylish 3 bedroom home. Bring your bikes and you'll have easy access to the Raccoon River Valley Trail. You can spend quality time together playing games and ping pong, or just sit outside and relax in the quiet small town atmosphere. You can make your own home cooked meal in the fully equiped kitchen or you can try the local restaurants.

4.93 out of 5 average rating, 150 reviews

Popular amenities for De Soto vacation rentals