Vacation rentals in Cape Girardeau County

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Top-rated vacation rentals in Cape Girardeau County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Farm stay in Frohna

4.98 out of 5 average rating, 104 reviews

The Weber Farm - Enjoy a beautiful 100 acre farm!

Enjoy a 125+ year old country home with large yard and beautiful shade trees located on a 100-acre farm in the rolling hills of SE Missouri. The house is very clean and spacious with 4 large bedrooms, comfortable beds, beautiful hardwood floors and a large living room. We have hand-made quilts and antique furniture throughout. The kitchen is fully furnished. Relax on our 40’ front porch with swing, by the fire pit or in a hammock. A perfect place for you to recharge from stress & busy schedules!

Aug 6 – 13

€ 148 per night

Guest favorite

Home in Jackson

4.93 out of 5 average rating, 267 reviews

The Rusty Owl-A Charming Victorian Dwelling

The Rusty Owl is a peaceful place with easy access to I-55. House has high speed (300 up and down) wifi. Jackson: Check out Flickerwood Arena, (9 minutes away... for ATV and barrel racing; horse shows and rodeos) Jackson History Center: Free. Open daily. Cape Girardeau: Live music and relaxation at The Library and 21 Taps. Hunter Valley Winery open weekends. 1 private lower level queen bedroom/ two private (1 queen, 1 twin) rooms and room with a antique full bed and a twin bed upstairs.

Nov 17 – 24

€ 107 per night

Guest favorite

Apartment in Cape Girardeau

4.97 out of 5 average rating, 352 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

May 19 – 26

€ 109 per night

Guest favorite

Guest suite in Cape Girardeau

4.96 out of 5 average rating, 111 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Sep 13 – 20

€ 85 per night

Guest favorite

Apartment in Cape Girardeau

4.94 out of 5 average rating, 172 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Oct 12 – 19

€ 129 per night

Guest favorite

Home in Cape Girardeau

4.97 out of 5 average rating, 117 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Nov 9 – 16

€ 254 per night

Guest favorite

Apartment in Cape Girardeau

4.85 out of 5 average rating, 533 reviews

Unique Design | Walk Downtown/River | .5 mile SEMO

At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.

Apr 10 – 17

€ 98 per night

Guest favorite

Barn in Cape Girardeau

4.95 out of 5 average rating, 108 reviews

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built only 2 years ago. Minutes from downtown Cape. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Relax in the front porch rocking chairs, hang out in the vaulted ceiling family area or game loft! Enjoy the sounds of nature around the fire pit, roasting marshmallows and watching the sunset. Near Trail of Tears and walking distance to classic dive bar/burger joint.

Mar 19 – 26

€ 222 per night

Guest favorite

Treehouse in Cape Girardeau

4.98 out of 5 average rating, 59 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Apr 6 – 13

€ 282 per night

Guest favorite

Home in Cape Girardeau

4.92 out of 5 average rating, 163 reviews

College town Charm: Minutes from Downtown Cape

EXCELLENT LOCATION near downtown riverfront Cape! Enjoy live music, local dining/coffee, shopping, casino, and seasonal steamboat rides downtown. Less than 5 min. from Southeast Missouri State University & Southeast Hospital. Centrally located near wedding venues: Rusted Route, Deerfield, Watersedge, Sweet Pecan, and Country Club. 2 blocks from scenic Capaha Park. Home to Capaha baseball. This huge park includes play structures, basketball court, disc golf & fishing pond.

May 21 – 28

€ 154 per night

Guest favorite

Cottage in Cape Girardeau

4.98 out of 5 average rating, 178 reviews

Historic Cottage Walkable to Downtown Cape

This welcoming 3 bedroom, 2.5 bathroom brick German vernacular cottage on a tree-lined street is just 2 blocks away from the Mighty Mississippi River and historic downtown Cape Girardeau's shops, restaurants, historic sites, river walk, and SEMO's River Campus. This home has been restored with an eye for family gatherings and was built by Joseph Lansman in 1892. We were honored to receive the Judith Ann Crow Residential Historic Rehabilitation Award from Old Town Cape in 2021!

Jun 18 – 25

€ 182 per night

Guest favorite

Loft in Cape Girardeau

4.9 out of 5 average rating, 187 reviews

Riverwalk Loft 3

Historical building with modern amenities. We are located right in the middle of downtown life. With the excitement there will come noise from bars, live bands, and the occasional train. If you love staying where fun is happening, this ones for you. Please note: we are located above an arcade bar and you are a building up from the River wall. There is also a currently operational TRAIN track with TRAINS, that make TRAIN noises 200ft from our lofts.

Oct 5 – 12

€ 145 per night