
Vacation rentals in Semmes
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Semmes
Guests agree: these stays are highly rated for location, cleanliness, and more.

Downtown , Modern Spacious & Near I-10
Enjoy a little piece of Mobile, Alabama by staying at this centrally located townhouse near all the best restaurants and the hustle and bustle of downtown. This unique space is a minute from I-10 giving you easy access to the interstate and quick driving time to just about anywhere. Minutes from the convention center, cruise terminal, Washington Square, and the famous Callaghan's Irish Social Club. Spacious, clean, modern, and convenient are all descriptions for this cute, newly remodeled space.

Modern Cottage w/Cabana-15 min to Downtown
Relax in this very comfortable, peaceful, private, pristine, modern cottage while away from home. And please enjoy YouTube Premium on the main TV on us. It’s located close enough to the highway for easy access to beautiful beaches as well as the fun filled exciting Mobile downtown area. It very close to a large number of excellent eatery spots as well as a convenient Publix grocery store and a Super Center Walmart for purchasing all of your favorite items for your stay at the cottage on Kushla.

Adorable 1-Bedroom Guesthouse in Spanish Fort
Enjoy a private space to call home during your Spanish Fort stay, cozy detached guest house with full bath, kitchenette, dinning space and closet space with private entrance. Amazing location only 10 minutes away from Mobile Bay and five rivers delta with the best fishing in the area. US-98 Causeway offers some of the most popular Cafe/Bars and amazing seafood, Italian and Mexican dinning on the Bay. Also within 5 minutes of shopping centers, 20 minutes from Fairhope and 45 to Pensacola Beach.

Peach & Pine Cottage - Pet friendly in Midtown
Peach & Pine Cottage, named for its color palette and featured tree, is our third listing! In this home, we embraced the retro energy with pops of mid-century modern throughout and paid homage to the fab fifties in almost every room. You’ll feel both comfortable and relaxed in a space filled with mixed metals, pastel colors, & plenty of lighting. As always, we want you & your pets to feel at home. Checkout our other properties, Magnolia Belle & the Oak Haven, to see the experience we provide!

Peaceful Backyard Suite
Ideal for longer term stays. Enjoy the sounds of nature when you stay in this unique place. Shade trees can be seen through the fixed windows near the cathedral ceiling. Feels as though you are in a treehouse! 1 queen bed or couch for sleep. (Linens available). House is new and within a fenced yard. It’s to the rear of owner’s home and backs up to a flower nursery. Very quiet. Great place to study, work online, or just relax. Porch on front with swing. Ask about pets for short term. No cats.

The Bare Minimum Bachelor Pad 3 bed/2 baths
If you're looking for simplicity and comfort without the frills, you've found the perfect spot! Located in Semmes, Al near mobile. This 3-bedroom, 2-bath retreat is all about the basics, offering just what you need for a laid-back stay. No fuss, no clutter, just space to relax, recharge, and enjoy the essentials. With no distracting art on the walls or extra knick-knacks, this place is perfect for anyone who appreciates clean lines and an "everything-you-need-and-nothing-you-don't" vibe. 😊

The Den, Comfortable loft midtown
Come stay at the Den! A renovated yet vintage loft in Midtown Mobile. This property is located less than a five minute drive to Downtown Mobile. Close to Starbucks, and the new Aldi's and more. This apartment has been completely renovated with granite and features refinished, original hardwood floors. This is a large studio apartment that has a living space, queen size bed, and kitchenette. The kitchen has a coffee and tea bar, two burner range, microwave, dishwasher and toaster oven.

Historic Midtown • Walkable • 5 Min to DT • WiFi
Centrally located in charming, walkable Midtown Mobile’s Old Dauphin Way Historic District, my home is just minutes from: 🎭 Mardi Gras parade route (2 mi), USS Alabama (5.3 mi), GulfQuest Museum (2.8 mi), Saenger Theatre (2.6 mi), LODA District (2.6 mi), Ladd-Peebles Stadium (0.8 mi), and Convention & Civic Centers (2.9 mi). 🏥 Near USA Health (2.5 mi) & Mobile Infirmary (3.2 mi). 🏖️ Dauphin Island (45 mins). ✈️ 15 mins to Mobile Regional Airport with quick access to I‑10/I‑65.

Three Notch Cutie
Your family will be close to everything at this centrally located home located in the Tillman's corner area of Mobile, AL. The house is approximately 1/4 mile from a new Dollar General and 3 miles from interstate I-10. In 2024 we did an interior renovation of the house, so that it now features LED lighting, freshly painted walls, new floors, new appliances, a tile shower, granite countertops, and brand new furniture. We ask that you take care of our investment. Thank you!

Cozy South Alabama Home
Your family will be close to everything when you stay at this centrally-located place. Minutes from South Alabama (USA), Springhill College, Mobile Tennis Center, parks, golf, Mobile Art Museum, Fair Grounds, and much more. The home sits on a large lot easy to find. Large fenced back yard for you and your four legged family members to enjoy. Also has a large covered back deck to enjoy along with a gas grill. Walking distance to the park and Japanese’s garden.

{B A Y} Quiet Midtown Retreat with King Bed
Please take a few minutes to read our reviews and hear why guests love our place so much... we work hard to provide a five star experience for every guest we host. We know you will love it too! *We offer weekly and monthly discounts* Our duplex is situated in a very friendly, walkable neighborhood. Starbucks is just a short stroll down the street. Walking distance to Aldi, Guncles gluten free bakery, and Soul Caffeine coffee shop.

Haven on Hamilton
Cozy, private guest suite convenient to the interstate, airport and great local restaurants. Located just half an hour from Dauphin Island and historical downtown Mobile. Local attractions include the USS Alabama, Mobile cruise terminal, and more. You can have the quiet, country feel with all the convenience of city living.
Popular amenities for Semmes vacation rentals
Other great vacation rentals in Semmes

White House on University

Private 3-Room Suite Near Shops & Restaurants

Near Airport : Mobile, AL. #3

Private Room w/Bath - Unit 2

MasterSuite w/ Private Entry and Bathroom

I-65 Exit 19 Bedroom #2

Jaguar Retreat - Spacious 4 Bedroom @ USA

County living#1
Destinations to explore
- Florida Panhandle Vacation rentals
- New Orleans Vacation rentals
- Panama City Beach Vacation rentals
- Destin Vacation rentals
- Gulf Shores Vacation rentals
- Orange Beach Vacation rentals
- Miramar Beach Vacation rentals
- Santa Rosa Island, Florida Vacation rentals
- Birmingham Vacation rentals
- Pensacola Vacation rentals
- Tallahassee Vacation rentals
- Rosemary Beach Vacation rentals
- Gulf Shores Public Beach
- OWA Parks & Resort
- De Soto National Forest
- Biloxi Beach
- USS Alabama Battleship Memorial Park
- Magnolia Grove Golf Course
- Waterville USA/Escape House
- Fort Conde
- Ocean Springs Beach
- Alabama Gulf Coast Zoo
- The Track
- Ft. Morgan Fishing Beach
- Gulf Islands National Seashore
- Alabama Aquarium At The Dauphin Island Sea Lab
- Dauphin Island Sea Lab
- Fort Morgan State Historic Site
- The Hangout
- Lambert's Cafe
- Golden Nugget Casino Presidential Suite
- Hard Rock Casino
- Shaggy's Biloxi Beach
- Biloxi Lighthouse
- Big Play Entertainment Center
- Alligator Alley




