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House vacation rentals in Santa Cruz

Find and book unique houses on Airbnb

Top-rated house rentals in Santa Cruz

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious living area with a high ceiling supported by wooden beams features a modern kitchen and dining set. A comfortable sofa adorned with decorative cushions faces a dining table surrounded by chairs. Natural light illuminates the welcoming interior from large windows.
Home in Santa Cruz
5 out of 5 average rating, 12 reviews

The lodge door

Escape to the heart of the Colchagua Valley Enjoy a comfortable and quiet stay in our cabin for 4 people, located just 7 minutes from downtown Santa Cruz. Ideal for those looking to disconnect, perfect for exploring the local cuisine, visiting boutique vineyards and discovering all that the Colchagua Valley has to offer. The cabin is new and works with sustainable energy. Its peaceful surroundings and proximity to outstanding restaurants will make your experience unforgettable.

Top guest favorite
A comfortable living area is depicted, featuring a dark brown sofa with decorative pillows and a wooden coffee table. A large television mounted on the wall displays a nature scene. Art pieces and family photos are arranged on the walls, enhancing the homely feel.
Home in Santa Cruz
4.98 out of 5 average rating, 182 reviews

Casa de Luz, fully equipped with parking.

Cozy retreat in the heart of Valle de Colchagua Discover a warm, bright and positive energy-filled space in Santa Cruz. A cozy, fully-equipped house, ideal for relaxing, reconnecting or enjoying the wonders of the valley: vineyards, history, gastronomy and nature. Everything here is designed to make you feel at home and that special touch that only a home with soul can offer. Wi-Fi, full kitchen. Steps to the best vineyards Ideal for couples, families or solo getaways.

Guest favorite
A charming two-story house is set amidst lush greenery and landscaped gardens. The exterior features a combination of stone and stucco with a tiled roof, and large windows allow natural light to brighten the interior. Surrounding trees enhance the tranquil atmosphere.
Home in Santa Cruz
4.93 out of 5 average rating, 15 reviews

Provençal-style house

Keep it simple at this peaceful and centrally-located place. Cozy and bright country house, with an unbeatable location on the Colchagua Wine Route, just minutes from Plaza de Santa Cruz and the Museum. Close to restaurants and main vineyards. It has four bedrooms, one of them en suite, 3 bathrooms, a living room, a dining room, and two living rooms. A large garden with fruit trees, a gazebo, and a swimming pool. You can order breakfast or barbecue service separately.

Top guest favorite
Home in Isla de Yáquil
5 out of 5 average rating, 8 reviews

Colchagua industrial loft among vineyards

Sleep in a loft among Cabernet Sauvignon vineyards in the Colchagua Valley You'll enjoy a breakfast included in the rate with farm products. You can go horseback riding as a couple with a guide accompanying you You have bikes to travel In the loft you have firewood to use the fireplace or an outdoor stove Enjoy a private barbecue with a charcoal grill and a large table Enjoy with horses, sheep, chickens 24-hour check-in

Guest favorite
A comfortable living area features a light-colored sofa with decorative cushions, alongside a leather armchair. A wooden coffee table sits in front, and palm tree artwork decorates the wall. Large windows allow natural light to enter, and a view of the open kitchen is visible in the background.
Home in Santa Cruz
4.87 out of 5 average rating, 15 reviews

Casa Parrón

Have fun with the whole family at this stylish place to stay. Cozy house with excellent location and ample parking Enjoy a comfortable and relaxing stay in this spacious house, ideal for families or groups of friends. It offers space for up to eight people. In addition, the house has ample parking and is in an excellent location, perfect for a quiet getaway or extended stay. We look forward to seeing you!

Guest favorite
A two-story colonial-style house is featured, with a terracotta exterior and terracotta tile roof. A wooden gate marks the entrance, and a small tree is positioned next to the wall, adding a touch of greenery against the bright blue sky.
Home in Santa Cruz
4.86 out of 5 average rating, 201 reviews

Just like home...

Two-story colonial-style house, tiles, wooden gate closure. Decorated mostly with Raulí furniture. Cozy atmosphere, quiet neighborhood, quiet, ideal for resting away from noise. Close to Colchagua Casino, museum, plaza, bars, pub and restaurants. Uber contact for a known and trusted person. The house has private parking for two vehicles. Air conditioning, Wi-Fi, Netflix, and terrace for grilling.

Top guest favorite
A covered porch area features a round glass table with two chairs, alongside a small grass patch with a set of six white chairs surrounding a table. The entrance is framed by a wooden door beneath a sloping roof, with a clear blue sky visible overhead.
Home in Santa Cruz
4.97 out of 5 average rating, 77 reviews

Comfortable and quiet house.

Relax with the whole family at this peaceful place to stay. Beautiful house located a short walk from downtown Santa Cruz, close to tourist attractions, a mini-market, a square, and the city entrance. It has an equipped kitchen and spaces suitable for rest. With 4 single beds, two bathrooms with a washing machine, a comfortable terrace with a grill, Wi-Fi, and TV.

Top guest favorite
The exterior of the lodge is presented, featuring a modern design with large glass windows. The structure is supported by distinctive angled beams, surrounded by landscaped gardens with various plants and a gravel pathway. Open seating areas are visible on the spacious deck.
Home in Santa Cruz
4.97 out of 5 average rating, 243 reviews

LODGE ACACIA CAVEN

Lodge Acacia Caven Un espacio de lleno de tranquilidad y confort ,conectado con la naturaleza, a 4 km del centro de de ciudad de Santa Cruz, ubicado en parcela de agrado privada. Casa de 100 metros cuadrados con Hot Tub externo, Terraza, Fogón, estacionamiento propio, zona para asado y entrada independiente.

Superhost
A wooden porch is lined with large glass windows, allowing for ample natural light. A few wicker chairs are positioned near vibrant flowering plants, while a grassy area extends towards distant hills, enhancing the overall serene landscape.
Home in Pichidegua
4.8 out of 5 average rating, 46 reviews

Casa de Campo

In a house in the middle of a mandarin and avocado field. It has panoramic views of the valley, offering incredible sunsets. It has a suite room view and the rest of the beds are in a cabin on site, in the common area. It's a house designed to be together and enjoy with family or friends.

Top guest favorite
A tidy seating area features two comfortable armchairs and a small round table placed on a light rug. Natural light filters through a window, partially dressed with sheer curtains, while a piece of artwork adorns the wall.
Home in Santa Cruz
4.92 out of 5 average rating, 52 reviews

House in Santa Cruz, O'Higgins Region, Chile

Propiedad en sector Los Viñedos, Santa Cruz. Excelente ubicación, a minutos del centro y con acceso a servicios. Cuenta con amplio living-comedor con luz natural, 2 dormitorios, 1 baño, patio de servicio y estacionamiento. Construcción de calidad y bien equipada.

Guest favorite
An outdoor dining area is illuminated by string lights, featuring a rustic picnic table surrounded by comfortable seating. A fire pit offers warmth and a focal point in the space, complemented by a large palm tree nearby and lush green grass.
Home in Santa Cruz
4.81 out of 5 average rating, 145 reviews

Comfortable house with swimmingpool

In the middle of the wineyards under the smoke of Santa Cruz in the Colchagua valley, you find this country home with big private yard and swimmingpool. It has a terrace with a bbq and also an outside oven. Close to all the wineyard like Vui Manet.

Top guest favorite
An outdoor space features a serene pool surrounded by carefully arranged stones and rocks. Lounge chairs are placed along the poolside. Lush green grass extends throughout the area, while expansive windows offer views of the nearby vineyards and mountains in the background.
Home in Santa Cruz
4.94 out of 5 average rating, 16 reviews

Casa en Apalta

En el Valle de Apalta, que a su vez está inmerso en el corazón del Valle de Colchagua, se encuentra esta adorable casa de fascinante arquitectura, rodeada de viñedos y afamadas viñas que dan origen a los vinos más premiados de Chile.

Popular amenities for Santa Cruz house rentals

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Avg. price€ 38€ 50€ 53€ 49€ 47€ 50€ 49€ 48€ 46€ 43€ 40€ 40
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Quick stats about house rentals in Santa Cruz

  • Total vacation rentals

    Explore 60 vacation rentals in Santa Cruz

  • Verified guest reviews

    Over 1,410 verified reviews to help you choose

  • Family-friendly vacation rentals

    30 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    50 of Santa Cruz vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Cruz rentals

  • 4.9 Average rating

    Santa Cruz stays are highly rated by guests—averaging 4.9 out of 5!

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