
Vacation rentals in Panhandle Key
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Top-rated vacation rentals in Panhandle Key
Guests agree: these stays are highly rated for location, cleanliness, and more.
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Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panhandle Key vacation rentals
Other great vacation rentals in Panhandle Key
Guest favorite

Home in Marathon
4.95 out of 5 average rating, 44 reviewsFlorida Keys Oceanside Utopia
Superhost

Tiny home in Key Largo
4.67 out of 5 average rating, 298 reviewsWaterfront Pool, Beach, Dock, Kayaks
Superhost

Home in Key Largo
4.87 out of 5 average rating, 55 reviewsWaterfront Home 3/2.5,HotTub,2Sup,4Kayaks,Golf Car
Guest favorite

Bungalow in Islamorada
4.97 out of 5 average rating, 59 reviewsCastaway Island - Pool, Spa, Tiki Bar, Kyaks,Sup’s
Top guest favorite

Home in Marathon
5 out of 5 average rating, 51 reviewsMovie Theater | HotTub | Pool | Boat/RV/EV Parking
Guest favorite

Home in Marathon
5 out of 5 average rating, 10 reviewsChiquita Waterfront Canal Home
Top guest favorite

Condo in Tavernier
4.97 out of 5 average rating, 30 reviewsSalty Mermaid Ocean Pointe 4406
Top guest favorite

Condo in Marathon
4.96 out of 5 average rating, 25 reviews*NEW* Private Beach, pool & fully loaded kitchen
Destinations to explore
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- Everglades National Park
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- Zoo Miami
- Biscayne National Park
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- Cannon Beach
- Calusa Beach & Loggerhead Beach
- Cocoa Plum Beach
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- Theater of the Sea
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