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Vacation rentals in Panama Canal

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Panama Canal

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Apartment in San Felipe
4.96 out of 5 average rating, 262 reviews

In the heart of Casco, remodeled and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Top guest favorite
Condo in Bella Vista
4.98 out of 5 average rating, 107 reviews

Modern Stay | Prime Location | Pool, Rooftop & Gym

Enjoy a spacious, modern apartment with a standing balcony offering beautiful city and mountain views, right in vibrant, local Panama City on Calle 50. Prime location near the iconic Tornillo Building Walk to the Metro, Cinta Costera, Panama Bay, restaurants, bars, coffee shops, local eateries, and supermarkets Enjoy Wi-Fi, Smart TV, parking, pool, gym, workspace, plus an on-site restaurant, coffee shop, and rooftop bar with breathtaking 360° city views Great location & everything close by!

Guest favorite
A modern living area is featured, showcasing a large wall-mounted television surrounded by a lighted panel. Seating is provided by a dark sofa with decorative pillows. A round dining table is visible in the foreground, complemented by four black chairs. Tall windows offer city views.
Apartment in Panama City
4.85 out of 5 average rating, 73 reviews

Luxury Oceanfront Resort 22nd Floor View, 200°

Luxury oceanfront apartment on the 22nd floor with breathtaking panoramic views of Panama Bay, the skyline, and historic Casco Antiguo. Located on the famous Cinta Costera, this resort-style apartment offers 2 bedrooms, 2 bathrooms, luxury kitchen, 65” TVs, washer/dryer, and sleeps up to 6 guests. Enjoy spectacular sunsets from the balcony and access to infinity pool, gym, and premium amenities, just minutes from restaurants, nightlife, and Panama City’s top attractions.

Guest favorite
Apartment in Panama City
4.97 out of 5 average rating, 95 reviews

Ocean View | Rooftop Pool | Luxury Stay

Wake up to a stunning ocean view right from your window at BrisaMarina. This luxury apartment is located in the spectacular The Sands building, right on the Cinta Costera. The modern and cozy space features bright natural light, air conditioning, high-speed Wi-Fi, and a fully equipped kitchen for your comfort. You’ll be just minutes away from restaurants, beaches, and top attractions. Perfect for couples, business travelers, or weekend getaways.

Top guest favorite
A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.
Home in Distrito Arraijan
4.98 out of 5 average rating, 234 reviews

Tropical Haven with Pickleball/Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Top guest favorite
A cozy living area features a bright yellow armchair beside a sleek media console. A modern television is mounted above the console, which displays green foliage. The floor is adorned with a patterned rug, while the textured stone wall adds a rustic charm to the space.
Place to stay in San Felipe
4.95 out of 5 average rating, 103 reviews

Loft in Casco Antiguo, Joya Colonial

Welcome to a space where history, design and comfort merge in one of Panama's most iconic neighborhoods. This apartment, located in the heart of the Old Town, immerses you in the rich colonial culture and architecture, while offering you all the modern amenities for an unforgettable stay. ✔ Spacious ✔ Classic-modern design ✔ Equipped kitchen ✔ Private balcony ✔ Dreamy master bedroom ✔ High-speed WiFi and Smart TV ✔ An unbeatable location

Superhost
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in San Felipe
4.9 out of 5 average rating, 126 reviews

Loft 3b Old Town Best! It's 150 m2 (492 feet)

Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

Guest favorite
A modern living area features a white sectional sofa adorned with colorful cushions. A sleek coffee table sits in front of a mounted television. Large windows provide expansive views of the city skyline, enhancing the bright and airy feel of the space.
Apartment in Bella Vista
4.89 out of 5 average rating, 196 reviews

Beautiful Apt, Best Location 2BR

Beautiful apartment, high floor up, with 2 bedrooms, 2 bathrooms, walking closet, and essential closet for the second bedroom. Extra twin bed available in the apartment. High speed internet, 300Mbps by Wifi aprox. , 600Mbps by cable. Social area on the roof with swimming pool, gym, sauna and bbq area. The building location is excellent, We are walking distance for grocery stores, restaurants, bank, Hilton Hotel&Casino.

Superhost
An interior view showcases a modern, multi-level loft with a wooden staircase leading to the upper loft area. Soft lighting creates ambient hues throughout the open space, highlighting the kitchen and living areas, where stylish furniture is arranged for comfort. Exposed stone walls add texture.
Loft in Panama City
4.89 out of 5 average rating, 359 reviews

2B Loft Studio | Design By Paradox

Private 40 m² loft studio in Santa Ana, about a 5-minute walk from Casco Viejo. Loft Studio sleeps up to 3 guests with a Queen bed on a mezzanine and a sofa bed, plus a full kitchen, private bathroom, air conditioning, hot water, fast WiFi, dining space, and a 1.8 m desk. Enjoy a TV with Roku and host-provided Netflix, Disney+, Max, and Prime. Guests have access to the shared balcony, patio, and paid laundry.

Guest favorite
Home in Gamboa
4.86 out of 5 average rating, 111 reviews

BirdHouse — Gamboa, Panama Canal Rainforest

BirdHouse: Let's inhabit the space. Designed for people who want to experience the tropics, not shut them out. Open the screens, feel the breeze, listen to the rain, cool off in the pool, and wake to birds and howler monkeys. Located in historic Gamboa, BirdHouse is a place to slow down and experience one of the world’s richest tropical forests from the comfort of a thoughtfully designed home.

Guest favorite
Apartment in Panama City
4.92 out of 5 average rating, 63 reviews

Balboa Avenue Sky Suites

Modern Apartment with Spectacular Views on Balboa Avenue | 2 Bedrooms, 2 Bathrooms Welcome to your home in the heart of the city, where luxury, comfort and breathtaking views combine to offer you a unique experience. This elegant 2 bedroom, 2 bathroom apartment is located in the exclusive PH The Sands Apartments & Mall on Avenida Balboa, one of Panama's most coveted destinations.

Top guest favorite
A spacious living area features a dark dining table set for six, adorned with gold charger plates. In the background, a large beige sofa contrasts with the light-colored walls. Natural light is complemented by modern light fixtures, enhancing the openness of the space.
Apartment in El Cangrejo
4.92 out of 5 average rating, 133 reviews

Nice & Cozy 3-Bedroom Apartment!

Centric Apartment in the Heart of the City! This building is located in El Cangrejo, a centric, friendly neighborhood filled with a variety of restaurants, bars, casinos and shops. Everything you need is within a 5 minute walk. Popular areas such as Casco Viejo, the Panama Canal Locks, Causeway and main shopping malls are within a 10 minute drive.

Popular amenities for Panama Canal vacation rentals