Vacation rentals in Mule Key

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Top-rated vacation rentals in Mule Key

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Guest favorite

Condo in Key West

Boat Slip - Waterfront Condo - Key West Pool

Be among the first to experience this spacious waterfront Key West getaway, newly available as a vacation rental! Enjoy a heated pool, marina views, an oversized private balcony, and over 1,200 sq ft of living space, all just minutes from Duval Street. Complete with a full kitchen, free parking, elevator access, pet-friendly accommodations, high-speed WiFi, and a private boat slip. Perfect for boating, fishing, beaches, and everything Key West has to offer. Pet friendly. 10-min from EYW airport.

LocationFamilyLaundry

5.0 out of 5 average rating, 11 reviews

Top guest favorite

Hotel room in Key West

The Sanchez House Room #2

There is no better welcome to Key West than staying in local and famous folk artist Mario Sanchez's birth home. This home was built in the 1860's in the heart of the historic Gato and Merrero cigar factory villages. Featuring original Dade County pine construction, and located right on historic Duval Street, the Sanchez House is guaranteed to offer the historic atmosphere and living a part of Key West many visitors want to experience. Sit on the balcony and enjoy the trade winds & Ocean Breeze.

LocationFamilyAmenities

4.85 out of 5 average rating, 711 reviews

Guest favorite

A private conch cottage floats on calm waters, featuring a light green exterior with white trim. Spacious decks are present at the front and back, while paddle boards and kayaks are visible nearby, highlighting the connection to the surrounding nature.

Houseboat in Key West

Key West Outpost: eco-vacation

The Outpost is a unique experience. This is a place where you can be completely off the grid, but still have all of the amenities. Private conch cottage on the backcountry waters surrounding Key West. Enjoy watching the amazing wildlife from your private deck. You can paddle board, kayak or do some light tackle fishing right off the boat. You can even add eco-tours to enhance the adventure. We will take you out for arrival and bring you back on your departure day, via one of our other boats.

ValueFamilyBeach

4.95 out of 5 average rating, 84 reviews

Top guest favorite

Aerial view showcasing a waterfront property bordered by vibrant green mangroves. The calm turquoise water reflects the blue sky dotted with white clouds. A marina with docked boats is visible nearby, creating a serene coastal landscape.

Condo in Key West

Gorgeous Ocean View in Paradise, Close to Key West

This is paradise! Wake up to a gentle breeze and birds singing just outside your balcony. Watch the sunrise over the ocean and mangroves from your private balcony. Enjoy your privacy as you start your day, then venture out to explore all that Key West has to offer: water sports, quaint shops, delicious food, history all around you, and so much more! On property features: Pool, Hot Tub, Yellowfin Bar & Kitchen and Parking. Beach supplies included: Coolers, Snorkel Gear and Beach Towels.

ValueLocationIndoor spaces

4.99 out of 5 average rating, 141 reviews

Guest favorite

A comfortable room features a spacious bed with crisp white linens, positioned against a coral-themed accent wall. Natural light streams through a window with white shutters. A small dining table and chairs complement a kitchenette area, while a large mirror enhances the sense of space.

Apartment in Key West

At Mine | Lovely Suite steps from Duval Street

Beautifully renovated boutique hotel suite steps from Duval Street. Located on a quiet street, it offers a private pool and peaceful stay for vacationers and business travelers. The unit includes a comfy Queen bed, mini fridge, microwave, iron & board, hangers, TV, and AC. Enjoy Key West's warm weather year-round. This special place is close to everything, making it easy to plan your trip. Just a heads-up: Key West’s famous roosters love to strut and crow—part of the island charm!

FamilyValueComfort

4.86 out of 5 average rating, 1744 reviews

Guest favorite

Home in Key West

Old Town Key West Escape - The “Eyebrow Saltbox”

28 Night Minimum. Welcome to "The Saltbox"! 710 Ashe Street is a charming house circa 1889. This historic Eyebrow home offers classic elegance and history with modern comforts. A spacious living area, sleek kitchen, three tropically decorated bedrooms (1 King and 2 Queen Beds). 6 person max. Private and heated Cowboy pool. Conveniently located in Old Town, walking distance to shops and attractions and Duval St. Local Key West Artist Designed.

LocationValueBackyard

4.88 out of 5 average rating, 16 reviews

Top guest favorite

Apartment in Key West

Bella Vita: 1B/1B Condo for 2 Just Steps off Duval

1B/1B condo located in Old Town less than 1/2 block from Duval St. & a couple blocks from the Southernmost Point, Hemingway House & many other Key West attractions. Bella Vita accommodates 2 adults only and features a large porch with chairs & table, living room with leather sofa, galley kitchen with bar seating, king-size bed with Tempurpedic mattress, desk area, bathroom with large walk-in shower, wi-fi, sound machine, 2 Smart TVs & DVD players.

FamilyValueGetting around

4.98 out of 5 average rating, 566 reviews

A resort-style pool is framed by palm trees, with inviting lounge chairs arranged on either side. The clear water reflects the blue sky, while the beach and ocean can be seen in the background, providing a serene setting for relaxation.

Apartment in Key West

Signature King at Beachside Resort

Set on seven acres of property overlooking the Gulf of Mexico, experience luxury at Beachside Resort & Residences. Unwind in the perfect blend of adventure and relaxation in sunny Key West. On property, you can find access to our resort pool, ocean marina, and the ability to book a sandbar or sunset cruise. Don’t miss out on fine dining at our award winning restaurant, Tavern N Town, or grab a delectable meal poolside at Chicken Walk.

LocationValueKitchen

4.62 out of 5 average rating, 359 reviews

Guest favorite

A floating home is anchored in calm waters, featuring a sleek design with large windows. Two red buoys are visible alongside the vessel. A paddle board rests on the top deck, which is covered for shade, inviting guests to relax while taking in the surrounding nature.

Boat in Key West

“The Easy Way” Comfy, Practical, Convenient

Reconnect with nature at this unforgettable escape. Stay off Key West away from the crowds and listen to nature. Vessel “Easy Way” is perfect for up to 2 people. Come enjoy the amazing sunrise and sunset. Cook out on the balcony, watch fish, birds, stingrays, and dolphins go by. Vessel Easy Way has an outdoor shower, paddle board, and outdoor grill. This floating home is perfect for people who want to relax and enjoy nature.

LocationSleep qualityComfort

5.0 out of 5 average rating, 24 reviews

Hotel room in Key West

Silver Palms Inn & Historic Homes, Classic King C.

Classic king city/balcony offers an inviting island style retreat with soothing colors, a plush king bed, and tranquil city views. Enjoy high speed wired and wireless internet, a 40 inch LCD TV with cable, an iPod docking station, iron and ironing board, hairdryer, in room safe, microwave and fridge, pillow top mattress comfort, and daily housekeeping.

ValueLocationBathroom

4.85 out of 5 average rating, 81 reviews

Guest favorite

The Tiki Suite is presented on a wooden platform, showcasing thatched roofing and an inviting porch area. Two stand-up paddleboards are placed alongside the structure, with calm waters reflecting the clear sky.

Houseboat in Key West

Tiki Suites ~ Original Tiki ~ Floating Bungalows

Stay on the water in this one-of-a-kind Tiki Suite in Key West. This private floating bungalow blends boat life with comfort, featuring a custom bed, panoramic views, and direct access to the ocean. Swim, paddle, or relax in a hammock surrounded by nature. A peaceful, off-grid glamping experience you won’t find anywhere else. Accessible by boat only.

ValueLocationQuiet

4.91 out of 5 average rating, 562 reviews

Apartment in Key West

Apartment in Key west

1 bedroom apartment in a duplex house. Separated spaces Private entrance Very large living room area with coffee bar included. Tv with Roku Activity’s for kids( coloring pages, games & more) Newly renovated bathroom as well as the living room. Hot plate, full size fridge, microwave & pots and pans. NO SMOKING INSIDE.

ValueNearbyHospitality

4.8 out of 5 average rating, 5 reviews