Family-friendly vacation rentals in Mira Mesa, San Diego

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Mira Mesa, San Diego

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

A spacious outdoor patio area features a well-maintained green lawn, framed by lush foliage and colorful plants. The horizon showcases a serene sunset, blending warm hues of orange and purple across the sky, creating a peaceful backdrop for relaxation.

Townhouse in Poway

4.85 out of 5 average rating, 288 reviews

"THE VIEW" - Experience a Beautiful Vacation Home

Welcome to "THE VIEW" - our clean, modern home with a breathtaking view! A short distance from: -Downtown -Beaches -La Jolla/Del Mar -SeaWorld -Zoo/Safari Park -Legoland This home includes: -4 Bedrooms -2.5 Baths -Full kitchen, appliances, and amenities -Living room w/large sectional -Smart TVs -Nest thermostat -BBQ Grill -Furnished Patio -LED lighting, and more! Experience the magic of sunset from the comfort of our patio. Book your stay today and create memories that will last a lifetime!

Guest favorite

A private garden area features two large orange umbrellas shading wicker seating arrangements. Lush greenery and colorful potted plants surround the space, with a stone patio leading to a warm-toned guesthouse wall. A window on the guesthouse reflects natural light, enhancing the serene atmosphere.

Guesthouse in Kensington

4.97 out of 5 average rating, 584 reviews

Central & Serene Secret Garden Guesthouse

My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

Top guest favorite

The exterior of a two-story house is displayed, featuring a concrete patio area and large glass doors that open to the backyard. Lush greenery surrounds the space, providing a natural setting, while a shaded lounge area with chairs is visible under a patio umbrella.

Home in Rancho Penasquitos

4.91 out of 5 average rating, 161 reviews

West of Rancho Peñasquitos,easy access to freeway

This house is great for families and groups of friends, workers for their business trips. This 2000sq ft , 2 story house has 4 bedrooms/3 full bathrooms with 1bedrm and full bathroom DOWNSTAIRS. A suburban neighborhood that is also conveniently located for visiting tourist sites. Surrounded by a canyon with walking trails. About 8 miles away from Torrey Pines and Del Mar beaches with a lot of dining at Del Mar Village. Airport is just 20 minutes away. 15 miles from Legoland, San Diego Zoo.

Superhost

An open living space features a comfortable sofa facing a mounted television. A stone accent wall complements the modern design. In the background, a fully equipped kitchen and dining area are visible, with natural light streaming through large windows.

Home in Mira Mesa

4.83 out of 5 average rating, 232 reviews

Modern Kitchen Zen Backyard Putting Green with AC

Our recently modern remodeled 5 bedroom home is located in the heart of San Diego. From the living room front door you'll see through to the kitchen, family room, and straight into the wide backyard with a putting green. Set up perfectly for family gatherings. Kitchen comes fully equipped. - Thermador stove, down vent hood, microwave, oven, and wide island Backyard perfect for a gathering: Safe and clean for the kids to run around. Has putting green, fire pit, and multiple lounge areas.

Guest favorite

A tropical pool area is featured, showcasing a winding design with clear waters. A thatched gazebo and lush greenery surround the pool, and a water slide is visible cascading into the pool. Sunlight reflects off the surface, enhancing the tranquil environment.

Home in San Diego

4.96 out of 5 average rating, 119 reviews

Luxurious Home w/Hot Tub & Pool + Water Slide

This freshly painted (2025) tropical oasis is located in the Waterford Scripps Ranch community. The house has a large & inviting pool, a terrific slide for kids, a hot tub & a builtin BBQ. It's a perfect place for a family to relax & enjoy all that San Diego has to offer. It's a couple of miles from the lake w/ beautiful views, jogging, biking, canoeing, and more. It's centrally located in San Diego, <30 minutes from most things including downtown, the beaches, the Wild Animal Park & more.

Guest favorite

An open-concept living area is highlighted by high ceilings and large windows, offering natural light. A modern kitchen features wood cabinets and a white island, while a dining table with turquoise chairs accommodates several guests. A cozy seating area is visible in the background.

Home in Ramona

4.97 out of 5 average rating, 836 reviews

The Glass House - A Nature Retreat

Enjoy a unique retreat; 180 degrees of views from inside the home. Nestled at the end of a private road, our place is nearby great hiking and countryside wineries. The Glass House provides a magical space and nature retreat where individuals, couples, families and friends can gather together to re-connect with nature, each other, and themselves. The breathtaking mountain top views, the huge deck, hot tub, fireplace, and the open concept living space is unbeatable for the perfect getaway.

Top guest favorite

A cozy seating area is presented with a brown leather couch and a light-colored armchair, accompanied by a rustic coffee table. A lamp casts soft light, illuminating a wall featuring a photograph and decorative items on shelving. A patterned rug adds texture to the space.

Farm stay in Escondido

5 out of 5 average rating, 103 reviews

Peaceful new Tiny Home on farm, steps to wineries!

This new tiny home sits on a beautiful ranch in the middle of citrus and olive trees, with a vineyard as part of your view. It is near the Safari Park, wedding venues and is walking distance to 4 wineries! The property is gated so guests feel safe and sleep peacefully in the quiet of the country. You will love the fresh fruit, farm animals, and tranquility of the location - all while only being 4.5 miles off the freeway. This space is excellent for couples, friends and solo adventurers.

Guest favorite

A bright kitchen area features vaulted ceilings and large windows offering views of the surrounding greenery. The space includes modern appliances, a mini island with bar stools, and light-colored cabinetry, creating an open and airy atmosphere.

Guest suite in Santa Fe

4.94 out of 5 average rating, 159 reviews

Private Apartment - Secluded 2 Acre Estate/Orchard

Enjoy our serene and beautiful loft apartment in south Rancho Santa Fe. Quiet and completely private retreat on garden like 2 acre farm estate with orchard. Kid friendly and just minutes from the beach, fair grounds, restaurants, golf, horse riding, hiking, and shopping. This spacious 900 sq ft. getaway includes wifi, 2 smart ROKU TVs, full kitchenette, dining table, King bed, additional two twin XL beds. 7 miles from the beach, 2.5 miles from Trader Joe's and multiple restaurants.

Superhost

A modern studio suite features a queen bed dressed in crisp linens, complemented by a full-size leather sofa and a wooden coffee table. Light streams through a lace-panel curtain, illuminating vibrant wall art. A mini refrigerator is positioned nearby, adding convenience to the space.

Tiny home in Rancho Penasquitos

4.84 out of 5 average rating, 173 reviews

SUPER! Private Studio w/WD 2 Mins from Freeways!

Entire Private Studio Suite. Brand new up dated entire suite with 1 Queen Bed & 1 bath. Ideal for couples, solo adventurers, and business travelers. Studio is fully equipped with 1 queen bed, full size leather sofa, working desk, kitchenette meant for light food warm, mini size refrigerator, single sink meant for light cup and dish wash, AC, heater. All new furniture, mattress, beddings. All shops, restaurants, cinema, hiking trails within minus drive about 1-5 miles away.

Top guest favorite

A cozy guest suite features a king size bed with a multicolored quilt and matching decorative pillows. A comfortable black couch is positioned beside a low coffee table, with a wall art piece displaying a beach scene above. Natural light streams in through the window.

Guest suite in Clairemont Mesa

4.91 out of 5 average rating, 285 reviews

Cozy Guest Suite -Private 1 bd/1 bath

This private guest suite is centrally located to all of the wonderful attractions that our beautiful city has to offer. The suite has it's own private entry and is completely separated from the rest of the house. It is fully equipped with a king size bed, a comfortable couch, table, coffee, fridge, microwave, TV, and AC/heat. It has it's own private bathroom with bathtub and shower. If you are traveling with children, we can provide a portable crib, and/or air mattress.

Guest favorite

Natural light fills the airy sleeping area, featuring a spacious queen-size bed and cozy seating. French doors open to a serene view of the tree-filled canyon, while large windows ensure a bright atmosphere. A decorative plant adds a touch of freshness to the inviting space.

Guesthouse in Clairemont Mesa

4.89 out of 5 average rating, 198 reviews

Serene San Diego Canyon Getaway

Our cozy studio-style guest house perched above a tree-filled canyon is a serene getaway in the center of San Diego, just a few minutes' drive to all local attractions and most of our other institutions (colleges, universities, hospitals). The casita is comfortable for two or a small family, with full kitchen capacity to prepare at-home meals. Our weather here is temperate, but if the weather gets hot, we have a silent mini-split A/C unit to cool the casita as needed.

Top guest favorite

The living room features two light-colored sofas adorned with decorative pillows. A round, tufted ottoman stands in the center, complemented by a side table holding decorative items. Natural light filters through the window, and a staircase is visible in the background.

Townhouse in University City

4.86 out of 5 average rating, 146 reviews

UTC Venetian 3 miles La Jolla Beach UCSD Scripps

Approx 3 miles from the most famous La Jolla beach! Only a mile away from UCSD with bus stop right outside the side gate. One of the nicest and most convenient locations in UTC/La jolla. Located right by the 5 and 805 freeway w/52 nearby! Walking distance to Wholefoods, Chase & Citi bank, CVS, Rubios, Nordstroms Rack, Starbucks, CPK, Trader Joes, Ralphs, Wells Fargo, Ross, Best Buy, AMC movie theater, and many restaurants ALSO Westfield Shopping Mall and so much more!