Vacation rentals in Middlesex County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Middlesex County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite

A modern living area features a sectional sofa, two accent chairs, and a coffee table. A flat-screen television is mounted on the wall, while natural light filters through stylish sheer and blackout window coverings.

Home in London

Spacious Two Bed Executive Suite Private Entrance

Relax with the whole family in this spacious, peaceful Two-Bedroom Executive Suite. Enjoy a modern, private access, fully equipped space with cozy bedrooms with private laundry and office space, a fully stocked kitchen, open concept living space. Easy access to restaurants and shopping centers to full fill all your needs. Movie theatres, athletic facilities and other attractions all within a short drive. Perfect for families, small groups, or business travelers seeking comfort and convenience.

4.88 out of 5 average rating, 102 reviews

Top guest favorite

A bright and airy living area features vaulted ceilings and large windows that allow natural light to fill the space. Modern furnishings include a spacious sectional sofa arranged around a low table, complemented by a dining table nearby. Decorative items add subtle charm to the room.

Apartment in Port Stanley

Stunning harbour front suite w/ exceptional views.

Sit back, relax, and watch boats pass by from The Bridgeway, a beautifully renovated suite in the heart of Port Stanley Village. Ideally situated beside Kettle Creek and the historic Lift Bridge, it’s steps from shopping, entertainment, marinas, award-winning restaurants, and a short, scenic harbour walk to Port Stanley’s beaches. This bright, spacious suite features a large open-concept living/kitchen area with one-of-a-kind panoramic views overlooking the harbour — the perfect spot to unwind.

4.99 out of 5 average rating, 113 reviews

Guest favorite

A dining area is highlighted by a glass table adorned with a decorative bowl and fresh flowers. Dark walls are complemented by elegant white trim, and a vintage mirror reflects soft light. An artwork of a woman grace the wall, adding a touch of sophistication.

Home in London

Elegant Downtown 3BR Main-FL Home | Free Parking

Enjoy exclusive use of a bright, renovated 1,200+ sq. ft. main-floor residence in a detached bungalow near DT London. The home features 3 comfortable bedrooms, a fully equipped kitchen, a spacious living area, a full bathroom, in-unit laundry, keyless entry, speedy Wi-Fi, a 65-inch Roku TV, heating and AC, and free on-site parking. Steps from Victoria Park, Canada Life Place, Covent Garden Market, and vibrant shops & cafes. With UH, UWO, and Fanshawe C nearby, convenience is at your doorstep.

4.92 out of 5 average rating, 300 reviews

Top guest favorite

A modern studio apartment is presented, showcasing a spacious sitting area with a large flat-screen television mounted above a contemporary electric fireplace. The open kitchen features updated appliances and a dining table for four, complemented by warm lighting and wood accents.

Guest suite in London

Modern and private guest suite

We've recently renovated our basement to create a stylish, modern, cozy and quiet guest suite. There is a side entrance that opens directly onto stairs taking you down to the unit. It has a locking metal exterior door for sound-proofing and security. The unit is a bright studio apartment with three large windows, a full kitchen, sitting area with tv and fireplace, dining table, queen-sized bed, walk-in closet and your own private bathroom with a five-foot shower. With extensive sound-proofing!

4.98 out of 5 average rating, 247 reviews

Top guest favorite

Apartment in London

Modern Guest Suite with Private Entrance

Welcome and enjoy your stay in London's most desired quiet neighborhood. We have a spacious Walkout basement with a private entrance and Lockbox for self check-in and check-out. Minutes away from amenities like Tim Hortons, Bus stop, YMCA, Maisonville Shopping Mall and trails. 10 minutes drive to Western University/Fanshawe College and 15 minutes to London's Downtown or Airport. Need a hot drink, we offer a Keurig coffee maker with complimentary coffee pods, kettle, tea, sugar and sweetener.

4.96 out of 5 average rating, 160 reviews

Top guest favorite

The living area contains a comfortable sofa and two green armchairs, with a wooden coffee table in the center. A television sits atop a white entertainment unit, and large windows provide a view of nature outside. Light curtains create a bright and airy atmosphere.

Apartment in London

Riverfront Retreat Near Downtown

City of London Construction Notice: Potential for noise. Please see other details for more info Welcome to our inviting 1-bedroom, 1-bathroom apartment retreat near downtown! Featuring a private balcony overlooking the Thames river and a beautiful trail directly behind the house. All amenities, wifi, laundry, and Netflix included. Enjoy the convenience of being near downtown London. 10-15 minute walk to Budweiser Gardens, Downtown, and a 5 minute drive to Western University.

4.93 out of 5 average rating, 245 reviews

Superhost

A serene bedroom is presented with a queen bed adorned in nature-themed bedding. A large mirror stands beside the bed, reflecting soft natural light from the window featuring light curtains. A wall art piece depicting a forest landscape enhances the calming ambiance.

Guesthouse in London

Charming Guesthouse Nestled Away

Nestled away in the heart of Old East Village in London Ontario. This guesthouse located in the backyard of a beautiful wooded lot is secluded away from the street and neighbors leaves it for a quiet, uninterrupted vacation. Outdoor covered patio, hottub and lounge area available for those sweet summer night hangouts. Minutes away from some of the best entertainment and dining London has to offer! Queen Bed in bedroom. Pullout couch in living room.

4.89 out of 5 average rating, 221 reviews

Top guest favorite

The exterior of a spacious, white home is showcased against a clear blue sky, surrounded by lush green trees. A large deck extends from the second floor, offering an outdoor space. The entrance features a wooden door, and a gravel driveway leads to the garage.

Home in Fingal

Port Talbot White House- With Pickleball Court!

Beautifully renovated 6000 square foot home nestled amongst the trees of the Port Talbot Estate. The White House has it all! A private Lake Erie beachfront (shared only with the other 2 cottages on the property,) endless hiking trails, beautiful cliff bluffs and a winding creek that's perfect for a morning canoe ride through the forest. Converted riding arena is now home to 2 pickleball courts as well as ample room for activities!

4.98 out of 5 average rating, 120 reviews

Top guest favorite

A hot tub is situated on a spacious deck surrounded by lush green trees, providing a serene forest backdrop. Nearby, a glass-top table with several chairs offers an inviting space for outdoor dining. Sunlight filters through the leaves, creating a calming atmosphere.

Home in Southwold

Nature Lover's Luxury Paradise

Nature Lover's Luxury Home in the woods. Creek's Edge Estate is a beautifully decorated home that is nestled on 10 acres of private woods. Minutes from London, ON this 4BDRM+3.5 BATH home sits next to some private hiking trails. Enjoy the sounds & sights of nature while relaxing in the hot tub. A beautiful escape for couples, families or groups looking to relax and recharge. Too many amazing amenities to list!

4.97 out of 5 average rating, 213 reviews

Top guest favorite

The cottage exterior is showcased under soft evening lighting, with floor-to-ceiling windows revealing indoor spaces. A wood-fired hot tub and outdoor seating area are visible in the foreground, surrounded by trees and a decorative string of lights enhancing the outdoor ambiance.

Cottage in Grand Bend

Priolo on the Trail: Nordic Spa w Beach Access

Immerse yourself in Japandi living with this Boutique Luxury Cottage that will captivate and connect you to its natural surroundings. Explore Grand Bend as never before, with proximity to the Pinery trails, a close walk to the deeded beach or recharge in our Nordic inspired backyard spa. Escape the city and build a vacation memory with family and friends. Follow us on @Priololiving on IG

4.99 out of 5 average rating, 113 reviews

Top guest favorite

A charming brick house is framed by lush greenery and well-maintained shrubs. Stone steps lead to the front door, which is flanked by two trees. The driveway is paved with light-colored stones, enhancing the inviting exterior of the home.

Home in North London

Best location in the city !

Experience the Ultimate Getaway for Large Groups in London, Ontario! Welcome to our spacious and inviting Airbnb. Whether you're planning a family reunion, a weekend getaway with friends, or a corporate retreat, our beautiful property is the perfect choice to accommodate up to 10 people comfortably. Short term accommodation license #202600219

4.97 out of 5 average rating, 194 reviews

Top guest favorite

An open living and dining area is visible, featuring a dark dining table with four seats. Two bar stools are positioned at a large kitchen island, while modern kitchen appliances line the counter in the background. Natural light illuminates the space, enhancing its inviting feel.

Guest suite in London

Spacious Basement Unit in Byron

* Beautifully renovated Basement Unit Apartment - owners live upstairs. * 2 bedrooms, 1 bathroom, in-suite laundry. * Quiet crescent in safe Byron neighborhood. * Separate heat pump with heating and cooling capabilities, plus additional heating elements for each bedroom. * Self check-in and check-out.

4.98 out of 5 average rating, 120 reviews