
Vacation rentals in Mesopotamia
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Top-rated vacation rentals in Mesopotamia
Guests agree: these stays are highly rated for location, cleanliness, and more.

A wooden cabin in the El Retiro Antioquia forest
Imagine sleeping in a wooden cabin in a king-size bed with the lull of the river's sound. When you wake up you will feel like you are in a treehouse overlooking the snowflakes full of birds, going down to the garden with bare feet, having breakfast on the deck and seeing the horizon. During the day, walk, go to the river and the waterfall, get to the stone bathroom and the whirlpool, sit in the hammock, read, and at night light the fireplace (salamander), have a glass of wine at the kitchen counter with your partner, family, and friends.

'UNICO' comfort, luxury and relaxation
Fascinating, fully comfortable apartment, not suitable for parties. The perfect combination of luxury and comfort. Upon entering, you'll find a quality living room with every detail of the decoration highlighted, and a fully-equipped kitchen to satisfy your tastes. A pleasant view, 2 comfortable rooms. The master suite features a bathroom, dressing room, and a spectacular queen-size bed. The guest room has a beautiful semi-double bed and a single bed, 24-hour surveillance, private parking, and more.

Cozy Apartment La Union. (Ant)
Create unforgettable memories in this unique and family-friendly accommodation, with an exceptional location and everything you need to have a comfortable stay in this magical town in eastern Antioquia. This space has been created to offer comfort and tranquility, ideal for travelers and families. The accommodation has a master bedroom and a secondary bedroom with a bunk bed and an extra bed, a private bathroom, a fully equipped kitchen and a living room with a sofa bed, an ideal space to share.

Foresta: Modern cabin with views of the rock
FORESTA is a modern cabin created with love for you to have an unforgettable stay in the middle of nature, with total comfort. Enjoy the privileged views from the deck, chill out in the jacuzzi, watch the dozens of birds that visit us or have a chat by the fireplace in the living room. FORESTA is a great launchpad to explore Guatape, climb the rock and do kayaking, jet-ski, wakeboard, sailing, paraglading, horseback riding, hiking, getting a helicopter ride or having an ATV tour. You choose!

Cabin with jacuzzi, private river and natural pool
Enjoy incredible privacy in the beautiful nature of Cocorná. Relax in the jacuzzi or enjoy the beautiful river with a private terrace next to a naturally created pool that belongs exclusively to this property. The cabin features a beautiful bathroom, a king size bed, Wi-fi, a TV with Netflix, and a kitchen equipped with all cooking utensils including a barbecue. We also organize various activities including paragliding and rafting. We offer transportation. Breakfast is included! (to prepare)

Entreaguas Cabin
Intimate glamping surrounded by forest, accompanied by the constant sound of a stream and birdsong. A wooden A-frame, full of natural light and surrounded by greenery, ideal for slowing down and enjoying without rushing. It has a queen size bed, full bathroom, equipped kitchen, cozy living room, private deck, air conditioning in the room and an outdoor area with a fire for long nights. A place to toast, chat, disconnect from the world and awaken calm, between El Retiro and La Ceja.

Cabin 8 min from JMC International Airport
Nature & View just 8 min from JMC Airport Ideal for couples or travelers in transit. Our cabin offers a view of the valley, a quiet atmosphere, self check-in, an equipped kitchen, fast wifi, and all the comforts to relax. For your convenience, there are restaurants with home delivery and inside the accommodation you can buy cold drinks and snacks when you need them. 🚘 Trusted Uber driver Relax, order your favorite food and enjoy the view. Book your date!

☼♥Villa Serena ♥☼ 360° Views-Nature-Serenity
* An incredible house with gorgeous 360° views* * 143 m² / 1539 ft² house size * Private Deck. Views of valley/Rionegro/Airport * Views of mountains * Privacy gate. Alarm. Parking for 5+ Cars * Fully stocked and equipped kitchen * 1 km / 0.6-mile dirt road to the house (any car will access) * There are two homes on the property, the main, larger house is Villa Serena where you will stay, the second home has a separate entrance and is not offered in Airbnb.

Cabin with Jacuzzi 8 min from JMC Airport
Welcome to Quimera Ecolodge, a charming chalet located in a natural paradise paradise just 10 minutes from José María Córdova Airport. At Quimera Ecolodge, every corner has been designed to offer you a unique experience, combining comfort, sustainability, and an authentic connection with the natural environment, ideal for those who want to escape the hustle and bustle of the city without losing proximity to comfort.

Casa del Leñador | Secluded nature retreat
🪓 Retiro Cabin – Casa del Leñador is the house of our dreams. A small, cozy tiny home surrounded by nature. The perfect place to spend a few days as a couple, a family weekend, or work remotely in an environment without distractions. Wake up to birdsong at dawn and enjoy a campfire on the deck at dusk. At Retiro Cabin you will have total independence and an unparalleled view of the countryside in eastern Antioquia.

Mountain retreat: sounds of silence # 1
Discover tranquility in this cozy retreat surrounded by nature. Our cabin, built in wood and with a modern and warm design, offers a perfect space to rest, read, contemplate the landscape or simply enjoy the silence. From its terrace or large windows you can admire endless mountains, golden sunsets and clear skies that invite calm. Inside you will find a comfortable and well-equipped atmosphere.

Cabaña Roble - A forest retreat
We are located in a native oak forest in the village of El Plan, near Medellin. The 50m2 loft-style cabin that blends with nature on a private 2-block lot. Experience this magical place with fresh air, outdoor fire pits, hiking, and reconnection. Near the cabin you will find a delicious bakery, organic vegetable crops, restaurants, and narrow streets for walking and exploring.
Popular amenities for Mesopotamia vacation rentals
Other great vacation rentals in Mesopotamia

Tiny House La Ceja Antioquia

Dulcinea cabin, jacuzzi with a view of the mountains

Nordika House: Ideal for photography and relaxation.

Luxe Cabin for rest in Llano Grande, jacuzzi, BBQ

Casi Cielo! Heaven's Edge

Comfortable Loft with a Spectacular View of the Great Plain

Luxury 24th Skyline • Private BathTub • Pool & Gym

Cozy country house close to waterfalls and pool
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