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Vacation rentals in Isthmus of Panama

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Top-rated vacation rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.95 out of 5 average rating, 19 reviews

Casa de Campo en Olá, ríos, cascadas, Los Picachos

Finca La Terapia hace honor a su nombre, se encuentra entre las montañas del pintoresco pueblo de Olá de Penonomé, en la cual podrás desconectarte del ajetreado día a día de la ciudad. Cuenta con 42 Hectáreas privadas para explorar la naturaleza. El distrito de Olá, se caracteriza por tener lo mas hermosos paisajes Naturales entre los que podemos mencionar, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, entre otros a muy poco minutos de la Finca.

Top guest favorite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique
4.98 out of 5 average rating, 47 reviews

CARA AL MAR Cacique (Parque de Portobello)

Une maison ! véritable îlot de verre au cœur de la jungle ! Au beau milieu du Parque National de Portobello (accès uniquement en 4x4 AWD) blotti au sommet de la colline, entre ciel/mer, à l'abri de tout regard, une maison transparente où le verre épouse la nature de tous côtés créant une connexion unique entre l'intérieur et l'extérieur, ideal pour se reposer, se déconnecter, confortable, spacieuse, fraîche (clim centrale), exclusive. Elle est le témoin d'un spectacle grandiose qui vous attend !

Top guest favorite
An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.
Home in Costa Esmeralda
4.98 out of 5 average rating, 190 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Guest favorite
An aerial view captures the layout of Tubasenik, showcasing a triangular island adorned with numerous palm trees and traditional cabins. A sandy beach gently curves around the island's edge, while boats are visible along the shoreline, complementing the clear turquoise waters surrounding the paradise.
Hut in San Blas Islands
4.91 out of 5 average rating, 118 reviews

San Blas islands, Tubasenik cultural getaway

Immerse yourself in the stunning beauty of Guna Yala, a paradise of crystal-clear waters and white-sand beaches. Explore secluded islands, relax under swaying palms, or snorkel vibrant coral reefs teeming with marine life. This experience goes beyond typical tourism—it’s a journey into the heart of the Guna culture, an indigenous community that cherishes its ancient traditions and deep connection to nature. Discover exclusive gems of the archipelago and make your adventure truly unforgettable

Guest favorite
Home in Playa Venao
5 out of 5 average rating, 5 reviews

Jungle Tiny House w/ Oceanview – Playa Venao

Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

Top guest favorite
Lush tropical gardens filled with vibrant flowers lead towards a traditional structure. The backdrop features rolling mountains, partially shrouded in greenery, under a clear blue sky. A variety of plants create a peaceful natural setting, inviting exploration and observation.
Farm stay in Boquete
4.92 out of 5 average rating, 289 reviews

Casitas in Butterfly and Honey Farm

Romantic setting, immersed in nature and yet close to town. Fibre Optic Internet. Nestled in extensive tropical gardens on a traditional Boquete Coffee Estate. Abundance of birds, feeders and native bee hives. We are home to Panamas largest butterfly exhibit and specialty honey company. We offer a hearty breakfast. We can accommodate 4 px but booking price including breakfast is for 2px. We charge an additional $15 per person over 12 yrs, an additional $10 for children under 12 yrs

Top guest favorite
The image features a stylish outdoor pool surrounded by lounge chairs, with elegant statues and lush greenery nearby. A distinctive tower, known as the Tornillo, rises majestically against a twilight sky, highlighting the modern architecture of the surrounding buildings.
Condo in Panamá
5 out of 5 average rating, 13 reviews

UrbanLuxuryintheCloudsFreeParkingclosetoeverything

Perched high above the city, this refined apartment offers a perfect blend of modern comfort and elevated style. Sunlight pours through expansive windows, revealing sweeping skyline views that feel both energizing and serene. The open living space is thoughtfully designed with clean lines, premium finishes, and a warm, inviting atmosphere ideal for relaxing or entertaining. As day turns to night, the city lights create a stunning backdrop, making this apartment a true urban retreat

Guest favorite
The exterior of Casa Serena showcases a spacious two-story structure with a warm, inviting facade featuring wooden accents. A wooden deck surrounds a private pool, and comfortable lounge chairs are positioned beside it. Umbrellas provide shade, while lush greenery complements the peaceful setting.
Home in Playa Los Destiladeros
5 out of 5 average rating, 13 reviews

Pedasí, Playa Los Destiladeros / Casa Serena

❤ Welcome to Casa Serena, escape to our stunning 3-bedroom ocean view house, perfectly located in Playa Los Destiladeros, an area of ​​beautiful beaches in Pedasí. This unique retreat offers a blend of modern luxury and coastal charm, ensuring an unforgettable vacation experience for you and your loved ones. Book your stay today and experience the magic of Casa Serena. Create lasting memories with your family and friends in this perfect ocean view escape.

Top guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 183 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favorite
An aerial view captures the lush greenery surrounding the treehouse, which extends over tranquil waters. The vibrant blue and green hues of the lagoon contrast with the shoreline, showcasing the natural beauty of the area. Mangroves frame the water's edge, emphasizing the secluded environment.
Treehouse in Provincia de Bocas del Toro
4.93 out of 5 average rating, 237 reviews

Cocovivo Mangrove Treehouse

This secluded loft-style treehouse sits on stilts above the water, 30 feet from our colorful coral reef. Transparent and airy but bug proof walls let you enjoy the fresh ocean breeze and views while keeping you safe and cozy. When a sloth comes to visit, no need to leave the house to see him! Blend in with the surroundings of mangrove, lagoon and jungle, and enjoy water and reef access from your own deck. Bright and airy, 100% eco-conscious.

Superhost
A tranquil garden scene is depicted, featuring a winding pathway of smooth stones and pebbles. Surrounding areas are adorned with various flowering plants and a small pond, enhancing the peaceful ambiance. Lush greenery is visible in the background, contributing to the serene atmosphere.
Farm stay in Santa Fe
4.89 out of 5 average rating, 301 reviews

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Top guest favorite
Home in Panama City
5 out of 5 average rating, 7 reviews

La Casa del Lago 2025

Casa nueva frente al lago en Cerro Azul, decorada por un arquitecto de D&G con muebles traídos de Bali. Cuenta con 3 habitaciones, 3 baños y 4 camas dobles , cocina equipada, BBQ, aires acondicionados y agua caliente. Cocina un delicioso BBQ con tus amigos frente al lago y disfruta los atardeceres desde una vista inigualable con acceso directo y kayak incluido.

Popular amenities for Isthmus of Panama vacation rentals