Some info has been automatically translated. Show original language

Vacation rentals in Doña Ana

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Doña Ana

Guests agree: these stays are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Top guest favorite
Guesthouse in Las Cruces
4.95 out of 5 average rating, 197 reviews

Quaint casita for 2

*Sep 2025 New bed/Aug 2024 New A/C mini split* Quiet cul-de-sac and peaceful landing spot within minutes to NMSU and Old Mesilla. Easy access to I-10 and I-25. Close to golf courses, shopping and the beauty of Las Cruces and Mesilla. Private entrance to casita, patio with dining table and a cozy bedroom, bathroom with tub/shower, WiFi, coffee station, refrigerator with small freezer, microwave. Wonderful hiking trails nearby and less than 60 minutes to White Sands National Park and ELP Airport.

Top guest favorite
An outdoor patio is enclosed by wooden fencing and illuminated by string lights. A hot tub sits invitingly to one side, while comfortable seating arrangements include a light-colored sofa and wicker chairs surrounding a small table. A door leads to the interior of the container home.
Farm stay in Las Cruces
4.92 out of 5 average rating, 133 reviews

Matchbox desert oasis hot tub, pet friendly!

Come experience a spa like feel in the desert where tranquility awaits! This container home is new,clean,relaxing, romantic and comfortable! Surrounded by farm land, with a clear view of the Organ Mountains, makes the night extra special spending it in the hot tub on the private patio or in the beach like sand zen landscape. You can go explore the next door property enter the hen den feed the chickens along with ducks, turkey, goats and horses! Free farm fresh eggs with every stay! No farm smell

Top guest favorite
A room features a spacious bed dressed in white linens, complemented by a dark blue throw pillow. Natural light filters in through sheer curtains. A small table with a microwave and refrigerator is visible, along with a black rug on the floor and a fan in the corner.
Guest suite in Las Cruces
4.93 out of 5 average rating, 598 reviews

Tiny Cute Cubby in Telshor Hills, Private Entrance

The Cubby is perfect for overnight or short-term stays. Zero contact check-in and check-out. Access to central Las Cruces. Close to NMSU, Mesilla Valley Mall, major medical centers, and major event facilities. Located in Telshor Hills, a quiet neighborhood with plenty of mature trees and vegetation. Close proximity to observatory, minimal light pollution. Gorgeous views of Organ Mountains and Tortugas Mountain (A Mountain). Ten minute drive from historic Mesilla. Close to various hiking trails.

Top guest favorite
An outdoor seating area is highlighted by four Adirondack chairs arranged around a glowing gas fire pit. A stone wall forms the background, while a dining set is visible in the distance, with soft evening light creating a serene atmosphere.
Home in Las Cruces
4.96 out of 5 average rating, 132 reviews

Luxury Southwest Retreat

Our home provides comfort, relaxation, and convenience in an invitingly decorated setting. Three rooms offer various sleeping arrangements to meet all of your needs. Choose from a king, queen, or twin beds. Fully equipped and thoughtfully appointed kitchen provides for all of your meal needs. Luxurious backyard with Adirondack chairs, gas fire pit, porch rocking chairs, and outdoor dining set allow for relaxing and socializing. Washer & dryer available, detergent and fabric softener provided.

Guest favorite
A spacious living area is showcased, featuring a large sectional sofa with contrasting black pillows. Light wood beams accent the ceiling, while large windows provide a view of the outdoor space. A modern coffee table sits on a textured area rug, enhancing the inviting atmosphere.
Home in Las Cruces
4.99 out of 5 average rating, 184 reviews

Modern Luxury Home

This Luxury Modern Home is made to suit all guests! Whether you are looking for a weekend getaway or a place for work and play, this home has everything to offer in beautiful Las Cruces, NM. Located in a brand new neighborhood near Red Hawk Golf Course and multiple family-friendly parks. Guests can rest peacefully in one of 4 bedrooms and enjoy amenities such as an outdoor grill, outdoor living area, lawn games, board games, and most kitchen items. High-speed Internet included and SmartTVs.

Superhost
A cozy living room is depicted, featuring a comfortable dark sofa with decorative cushions. A large piece of wall art displays two figures sitting on a bench, creating a sense of connection. An antique trunk and a decorative green vase enhance the inviting space.
Earthen home in Las Cruces
4.84 out of 5 average rating, 612 reviews

Southwest Mexican Adobe Casa Historic District

This wonderful adobe home with refrigerated air is located directly in the heart of the city the Mesquite Historic District of Las Cruces. This Mexican home combines the neighborhood classic adobe style. Directly across the street is a Mexican cafe and a coffee shop. Seven minute walk to downtown which has wonderful pubs and restaurants. This home is located directly across the street from my other two casitas that are listed in Airbnb. Dog fee $10.00 which can be left on the table.

Top guest favorite
The entrance features a traditional adobe archway with purple wooden doors flanked by a rustic ladder. A lantern hangs above the opening, while desert vegetation is visible to one side. The backdrop includes distant mountains under a clear blue sky.
Guesthouse in Las Cruces
5 out of 5 average rating, 269 reviews

Desert Peaks Casita

This lovingly remodeled casita just fifteen minutes from downtown Las Cruces is open, spacious, and comfortably equipped for any length stay. Take in the views of the mountains, watch the birds, or relax in the hot tub under the stars. Hike to the Organ Mountains-Desert Peaks National Monument via an arroyo from the casita, take a dip in the pool, or rest in the peaceful and tastefully decorated space. It is a perfect place for a quiet getaway or as a base to explore the area.

Guest favorite
An open living area is showcased, featuring a large sectional sofa facing a mounted television. A wooden coffee table sits in front of the sofa. The kitchen is visible, equipped with modern appliances and bar seating, while large windows provide ample natural light.
Home in Las Cruces
4.89 out of 5 average rating, 219 reviews

Modern Accessorized 3-Bedroom

This fully-furnished modern home is perfect for weekend getaways or longterm stays. With latest in appliances and style, the Powder River Villa offers the comfort of home with a luxury feel. Stream Netflix in front of the stacked stone fireplace, decompress in the pebble rain shower, or simply relax on the back porch to the beautiful New Mexico sunsets. This stylish space can be the romantic escape you're seeking or comfortably fit your group of 7.

Top guest favorite
A cozy interior space features a queen bed with a bright yellow throw pillow. A kitchenette with a microwave, mini-fridge, and sink is present. Natural light filters through the windows, which are adorned with blue curtains. A small table and chairs complement the room's design.
Guesthouse in Las Cruces
4.97 out of 5 average rating, 318 reviews

Cozy Casita w/private patio near Old Mesilla

This adorable casita is located just one mile from Historic Mesilla and 5 min from the interstate. The one bedroom 1 bath casita is perfect for visitors and travelers alike. Furnished with a queen bed, table and chairs and a outfitted kitchenette with microwave/air fry toaster oven/Keurig /double hot plate/ sink and mini-fridge. Also includes Wi-Fi , Smart TV (no cable), mini-split AC/ heater, and a private outdoor patio table and gas grill.

Guest favorite
A bright and airy studio features a spacious queen bed adorned with soft linens, complemented by side tables. Natural light filters through two windows, while a small dining area with a table and chairs is present, enhancing the overall cozy atmosphere.
Tiny home in Las Cruces
4.81 out of 5 average rating, 190 reviews

Studio w/queen bed, pets ok, 3 min to Farmer's mkt

Wonderfully serene little studio with a full kitchen. The bed is a queen memory foam, so it is very comfortable. Bring your dog with you, there is a nice-sized, secure yard for your pooch. There is everything you need to cook a small meal on the apartment-sized electric stove and oven, the kitchen is complete with a fridge, coffee maker, toaster, utensils, dishes, pots and pans, and fresh farm eggs from your host's farm!

Top guest favorite
A charming casita features a turquoise door and a light exterior, framed by subtle landscaping. The sky is filled with vibrant orange and yellow hues as the sun sets, creating a striking contrast against the white walls and windows.
Guesthouse in Las Cruces
4.99 out of 5 average rating, 176 reviews

Cozy Casita De Mesilla (Mesilla Cottage)

Cozy casita just steps from Old Mesilla’s historic plaza and coffee shops. Unwind in your private courtyard with a hot tub, or curl up by the fireplace inside the guesthouse. A kitchenette adds comfort for longer stays. Mesilla Bosque State Park by the Rio Grande is only 4 minutes by car—or a short bike ride—perfect for birdwatching, sunsets, and peaceful walks. The ideal spot for a romantic getaway or quiet retreat.

Top guest favorite
The exterior of the casita features a contemporary design with white stucco walls and a distinctive terra-cotta tiled roof. Landscaping includes small shrubs and gravel, with a driveway leading to a one-car garage. The entrance is marked by a decorative light fixture flanking the door.
Guesthouse in Las Cruces
4.92 out of 5 average rating, 150 reviews

Lovely Casita Suite (No Cleaning fee)

Unique place has a style all its own. New Casita in a new area close to professional Golf Course located at the foothills of the majestic organ mountains. Private entrance, kitchenette, living area that has a new sofa sleeper which can sleep up to 2 people. Has a private bedroom and private bathroom. Easy access to main highway that leads to shopping and restaurants.

Popular amenities for Doña Ana vacation rentals

  1. Airbnb
  2. United States
  3. New Mexico
  4. Doña Ana County
  5. Doña Ana