Saint Charles vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

Top-rated vacation rentals in Saint Charles

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Guest favorite

Home in Saint Charles

5.0 out of 5 average rating, 220 reviews

Rustic Handcrafted Japanese-Style Home by OldTown

Enter into the tranquility of a Japanese-style home interior near historic Old Town St Charles. The house is a symphony of handcrafted woodwork. The floors are polished bamboo and maple; mahogany, teak, mango, and oak furnishings. After taking a walk through Old Town or watching a movie in our home theater (theater seating, 86inch LG screen, Sony sound) or cooking a meal in our fully-equipped kitchen, you can drift to sleep in luxury bedding, Sleep2Win 14" mattresses and soft stone-washed sheets

Aug 25 – Sep 1

€ 276 per night
Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 483 reviews

301 Guesthouse SuperHost/Shop Discounts/Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Nov 6 – 13

€ 138 per night
Guest favorite

Home in Saint Charles

4.96 out of 5 average rating, 183 reviews

Sweet Escape Near Historic Main Street & MO River

Find a sweet escape in a cozy bungalow! Walk to Main Street in 15 minutes! This 4-bedroom house is the perfect location to explore St. Charles & St. Louis. Historic Main Street has shops, restaurants, & events on a cobblestone street. The semi-finished basement is a game-room with a pool table, ping-pong, foosball, & darts! There are board games & DVD’s as well. Outside, you have yard games & a fire pit! Comfortable beds with plush bedding & room-darkening curtains will ensure a restful night.

Nov 6 – 13

€ 164 per night

Popular amenities for Saint Charles vacation rentals

Stay near Saint Charles's top sights

Ameristar Casino Resort Spa St. Charles42 locals recommend
The Family Arena12 locals recommend
St. Charles Convention Center6 locals recommend
Hollywood Casino St. Louis20 locals recommend
Dave & Buster's10 locals recommend
Walmart Supercenter7 locals recommend

Other great vacation rentals in Saint Charles

Guest favorite

Home in Saint Charles

4.97 out of 5 average rating, 182 reviews

*HotTub* The Jewel on 5th-2br2b-near Historic Main

Nov 6 – 13

€ 286 per night
Guest favorite

Home in Saint Charles

4.96 out of 5 average rating, 109 reviews

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

Oct 3 – 10

€ 212 per night
Guest favorite

Home in Saint Charles

4.92 out of 5 average rating, 136 reviews

Clark Brick House w/ Pool | Historic St. Charles

Oct 24 – 31

€ 364 per night
Guest favorite

Condo in Saint Charles

4.94 out of 5 average rating, 142 reviews

Cozy Studio in Beautiful New Town St. Charles

Jan 2 – 9

€ 170 per night
Guest favorite

Home in Saint Charles

4.99 out of 5 average rating, 153 reviews

Charming Bungalow in Historic St. Charles, MO

Jul 30 – Aug 6

€ 359 per night
Guest favorite

Tiny home in Saint Ann

4.92 out of 5 average rating, 132 reviews

Forest Edge Tiny House | 8 Min to Airport

Apr 22 – 29

€ 159 per night
Guest favorite

Home in Dittmer

4.95 out of 5 average rating, 348 reviews

Honeymoon Suite Camp Skullbone In The Woods

Aug 20 – 27

€ 157 per night
Guest favorite

Home in Belleville

4.99 out of 5 average rating, 142 reviews

The Pool House 1-Bedroom Home with Hot Tub & Pool

May 26 – Jun 2

€ 114 per night
Guest favorite

Home in Godfrey

4.91 out of 5 average rating, 206 reviews

Private, Bluff-Top Cottage Above Mississippi River

Mar 9 – 16

€ 107 per night
Guest favorite

Cottage in Maplewood

4.98 out of 5 average rating, 360 reviews

Weaver Guest House

Aug 26 – Sep 2

€ 115 per night
Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 128 reviews

★ Blissful Historic Home Near Main St. ST CHARLES★

Oct 25 – Nov 1

€ 208 per night
Guest favorite

Home in St. Louis

4.98 out of 5 average rating, 506 reviews

Garden Cottage-Safe Private Parking!

Sep 11 – 18

€ 141 per night

Other great vacation rentals in Saint Charles

Guest favorite

Home in St. Louis

4.99 out of 5 average rating, 559 reviews

Cozy Barndominium Loft in Quiet Neighborhood

Nov 30 – Dec 7

€ 111 per night
Guest favorite

Loft in Washington

4.99 out of 5 average rating, 290 reviews

2nd Street Loft - Riverview

Jun 22 – 29

€ 107 per night
Superhost

Bungalow in Saint Charles

4.87 out of 5 average rating, 270 reviews

Perfect Location*Fun and Unique Decor* Cozy

Mar 14 – 21

€ 273 per night
Superhost

Loft in Saint Charles

4.8 out of 5 average rating, 41 reviews

City Loft in Saint Charles

Nov 3 – 10

€ 132 per night
Guest favorite

Home in Saint Charles

4.91 out of 5 average rating, 77 reviews

The Cardinal Nest A Cozy Cottage on Historic Main

Dec 26 – Jan 2

€ 146 per night
Guest favorite

Townhouse in Saint Charles

4.94 out of 5 average rating, 99 reviews

Cozy 2 bedroom townhome in the heart of St Charles

Jun 8 – 15

€ 136 per night
Superhost

Apartment in Saint Charles

5.0 out of 5 average rating, 5 reviews

Blue Suite @The Painted House

Oct 16 – 23

€ 147 per night
Superhost

Cabin in st charles

4.85 out of 5 average rating, 27 reviews

Chase's Cabin in The Sky

Sep 6 – 13

€ 129 per night
Guest favorite

Guesthouse in St. Peters

4.96 out of 5 average rating, 24 reviews

Maple Tree Enchanted Guest House 1 bedroom 2 beds

Oct 17 – 24

€ 93 per night
Guest favorite

Home in Saint Charles

4.95 out of 5 average rating, 83 reviews

Charming 2-Bed Brownstone in The Heart of New Town

Jul 14 – 21

€ 255 per night
Guest favorite

Home in Saint Charles

5.0 out of 5 average rating, 28 reviews

Family/4bd/2bth/Huge Yard/Playset/Ping-Pong/Arcade

Aug 13 – 20

€ 274 per night
Guest favorite

Home in Saint Charles

4.9 out of 5 average rating, 29 reviews

Stunning 1890s Home Sleeps 8!

Sep 11 – 18

€ 384 per night

Quick stats about vacation rentals in Saint Charles

Total rentals

200 properties

Rentals with dedicated workspaces

130 properties have a dedicated workspace

Rentals with a pool

10 properties have a pool

Pet-friendly rentals

80 properties allow pets

Family-friendly rentals

150 properties are a good fit for families

Total number of reviews

14K reviews

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Saint Charles?

    Yes! Work meets play with ease at over 130 vacation rentals in Saint Charles featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there pet-friendly vacation rentals in Saint Charles?

    Four-legged friends are welcome in Saint Charles. Choose from more than 80 vacation rentals for guests traveling with pets.

  • Are there Saint Charles vacation rentals on Airbnb with pools?

    Yes! Dive into the perfect getaway at one of over 10 vacation homes with pools in Saint Charles, available on Airbnb. Make a splash and soak up the sun in style!

  • Are there family-friendly townhouse rentals in Saint Charles?

    Saint Charles has more than 20 family-friendly townhouse rentals. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in townhouse rentals in Saint Charles?

    Experience the best of Saint Charles with our townhouse rentals, starting at about $90 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do house rentals in Saint Charles have a bbq area?

    Absolutely! We offer over 30 house rentals with a bbq area in Saint Charles. Enjoy a tailored experience with all the comforts you desire.

  • Do apartment rentals in Saint Charles have free parking?

    Absolutely! We offer over 30 apartment rentals with free parking in Saint Charles. Enjoy a tailored experience with all the comforts you desire.

  • Do apartment rentals in Saint Charles have wifi?

    Absolutely! We offer over 30 apartment rentals with wifi in Saint Charles. Enjoy a tailored experience with all the comforts you desire.

Destinations to explore