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Places to stay near Mark Twain Boyhood Home and Museum

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Top-rated vacation rentals near Mark Twain Boyhood Home and Museum

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
The kitchen features white cabinetry and modern black appliances. A spacious countertop offers seating at two metal stools. Natural light filters through the windows, illuminating the wooden flooring and classic tile backsplash.
Home in Hannibal

Little House in the Hollow

Private Hot Tub • Pet-Friendly • Walk to Mark Twain Cave & Winery • Near Downtown Hannibal Relax in this PRIVATE cozy retreat perfect for families, couples, or business trips. Enjoy a private hot tub, fenced yard, fire pit, BBQ, fast Wi-Fi, full kitchen, and self check-in. Walk to the Caves, Winery, Trolley & MT Live Show; downtown is 2 miles away. Explore, unwind, and enjoy a comfortable stay close to Hannibal’s top attractions. Only Airbnb to offer a discount to the 4 ticketed attractions!

FamilyValueComfort

4.94 out of 5 average rating, 240 reviews
Top guest favorite
A welcoming living area features a gray sofa and armchair, accented by decorative pillows. A round coffee table sits centrally, accompanied by a small plant. Natural light floods through multiple windows with sheer curtains, while a textured rug adds warmth to the space.
Home in Quincy

The Spring House!

Enjoy a stylish experience at this centrally-located 1890's farmhouse that has been completely transformed with all of the amenities you want and need. This convenient first floor apartment is located right across from one of Quincy's most iconic and favorite restaurant's, The Abbey! A fabulous space that features keyless entry, beautiful kitchen with quartz counter tops and stainless steel appliances, a wonderful onyx shower and comfortable beds with high end furnishings and lots of extras.

ValueFamilyGetting around

5.0 out of 5 average rating, 127 reviews
Guest favorite
A comfortable living space is featured with two dark leather sofas and a recliner. A cream-colored area rug in a cowhide pattern rests on the dark hardwood floor. Natural light streams in through two windows, with patterned curtains framing the view of the outdoors.
Home in Palmyra

Cozy country 2-bedroom home with a view.

Make some memories at this unique and family-friendly place. Enjoy the view of horses grazing while sipping your morning coffee on the front porch. Drive to historic Hannibal, MO (11 miles). Book a guided farm tour with the owners and/or a riding lesson on one of their many rodeo horses. This house sleeps 6 with a king bed, queen bed, and couch fold-out queen bed. Need more room? (See the other listing for this option). The hostess is right next door to assist with any of your needs!

ValueLocationWifi

4.89 out of 5 average rating, 204 reviews
Top guest favorite
A light-filled living area showcases a seating arrangement with a gray sofa and brown chairs, positioned beside a decorative table. A television is mounted above a fireplace, and a staircase leads to the upper level. A dining area with a round table is seen in the background.
Home in Quincy

Quincy Gem in Historic District

Large, spacious, fully renovated home nestled in Quincy's beautiful Historic District. This home is centrally located making it the perfect location for your stay. Enjoy the extensive coffee bar as our guests, play games, or walk to area Parks! This home would also make the ideal setting for a family reunion, bridal/baby shower, or cooperate gathering. Kids will enjoy the fenced in backyard! "Kids" of all ages will appreciate the basketball goal, ping-pong, & Foosball tables in garage!

FamilyValueBackyard

4.97 out of 5 average rating, 150 reviews
Top guest favorite
Apartment in Hannibal

The Library

The Library is your own hideaway in the heart of historic Hannibal. No one would suspect there is a charming apartment tucked away above a downtown business. This special place is close to coffee, restaurants, the river, shopping, bicycle rental, even a chocolate shop - making it easy to plan your visit. A quiet get-away with plenty to read. Because there are books and breakable items, and there are businesses downstairs and across the hall, we limit guests to no more than two adults.

LocationValueAmenities

4.9 out of 5 average rating, 60 reviews
Guest favorite
An antique wooden bed with a decorative headboard is centered against a textured brick wall. Soft pink bedding is arranged neatly on the bed. A small side table with a lamp and a colorful floral curtain is visible, complementing the warm tones of the wooden floor.
Home in Hannibal

Genevieve’s Federal House

This home is a fully restored 1 story Federal house, which you will have full access to. It is located close to the Mark Twain Boyhood Home, and right off Broadway. The house comes furnished with seating, furniture, and 2 Roku televisions. There are two bedrooms, one bathroom, a dining room, living room, and a kitchen. The home has central air conditioning and heating, washer and dryer, dishwasher, and a beautiful clawfoot cast-iron tub with shower. There is off street parking.

LocationValueNearby

4.93 out of 5 average rating, 127 reviews
Top guest favorite
Home in Hannibal

Molly’s Riverview Retreat

Step back in time at this historic home, built in 1844 by the territory’s first judge. Enjoy your morning coffee on the veranda where Molly Brown, famously known as the “Unsinkable Molly Brown,” once sat while visiting her sister and taking in views of the mighty Mississippi River. Explore the original hardwood floors and historic dining room, rich with stories of generations past. Walk to downtown attractions, restaurants, nightlife, and local festivals for a memorable stay!

LocationValueAir conditioning

4.97 out of 5 average rating, 128 reviews
Top guest favorite
The historic building features ornate green and white detailing on its façade, complemented by striped awnings above the windows. A tree is visible in front, enhancing the street view, while a bench is placed along the sidewalk, inviting visitors to enjoy the ambiance.
Apartment in Hannibal

Main Street Suite w River & Main St Views!

Located in the heart of Historic Downtown Hannibal. Bring back the nostalgia or start memories of your own by staying in this charming antique building, built in 1879. Newly renovated suite allows for modern amenities while still enjoying the Hallmark charm of the Main street and the birthplace of Mark Twain. Short walks to the Big Muddy Mississippi River, Lighthouse, Riverboat, shopping and restaurants. Take a short drive to the caves for the full Tom Sawyer experience.

FamilyLocationAccess

4.99 out of 5 average rating, 68 reviews
Top guest favorite
A hot tub is positioned in the foreground, surrounded by landscaped greenery. A spacious, historic home with a red brick exterior is visible in the background, including large windows and a welcoming porch. An outdoor fire pit with red Adirondack chairs is situated adjacent to the hot tub.
Home in Hannibal

Charming Escape - Private Hot Tub!

Step back in time & create unforgettable memories at this remodeled, historic home in downtown Hannibal, MO. Touting a rich history, this home was built by the founder of Storrs Ice Company! Ideal for families & Mark Twain enthusiasts, this home is located just steps from the charming downtown area, world-class festivals, and the Mississippi River! Get ready to relax in the hot tub, explore the town, & sip coffee in the sunroom with river views, in this large 4 bd home!

LocationValueBackyard

4.93 out of 5 average rating, 95 reviews
Top guest favorite
A well-equipped kitchen features modern appliances, including a stainless steel refrigerator and gas stove. A large island with a marble countertop provides seating for four. Light floods the space through overhead fixtures, enhancing the clean, organized layout that encourages home cooking.
Home in Quincy

❤️Quincy Quarters 2❤️

Quincy Quarters is a beautifully restored 1880’s Duplex with modern amenities and all the historic charm. This duplex has been home to families for 140 years. Bring your family and your pet and enjoy 140 years of history. Quincy Quarters is close to Oakley Lindsay Center, Blessing Hospital and Quincy University, it is blocks away from South Park and just a couple minutes from downtown Quincy.

LocationValueSleep quality

4.98 out of 5 average rating, 264 reviews
Top guest favorite
The charming exterior of the Rose Cottage is showcased with a welcoming front porch, adorned with hanging plants and decorative wrought-iron railings. A well-maintained pathway leads to the entrance, complemented by flowering planters, all under clear blue skies.
Cottage in Hannibal

The Rose Cottage in historic downtown Hannibal

Located at the tip of historic Main Street in downtown Hannibal and within easy walking distance of many Mark Twain attractions, restaurants, pubs, shopping, entertainment, etc. At the Rose Cottage, we strive to provide guests with a high quality stay in a cozy, relaxing environment where they can easily enjoy all that downtown Hannibal has to offer.

ValueFamilyCondition

4.96 out of 5 average rating, 166 reviews
Top guest favorite
Apartment in Palmyra

Front Porch Sunlit Studio on Historic Main Street

Bright, private studio within a historic home Comfortable sleeping area with quality linens Cozy fireplace and smart TV Kitchenette with fridge, microwave, coffee maker, oven, electric stove and dining table Private bathroom with tub/shower and plush towels Thoughtful storage and layout designed for comfort

LocationFamilyWifi

4.94 out of 5 average rating, 272 reviews

Popular amenities for vacation rentals near Mark Twain Boyhood Home and Museum

KitchenWifiPoolFree parking on premisesAir conditioning

Other top sights near Mark Twain Boyhood Home and Museum

Mark Twain Boyhood Home and Museum

43 locals recommend

Becky Thatcher's Diner

18 locals recommend

Rockcliffe Mansion

16 locals recommend

Rumor Has It

10 locals recommend

Bluff City Theater

10 locals recommend

Mark Twain Riverboat

8 locals recommend

Condo rentals with wifi

Top guest favorite
A living room area displays a comfortable green couch paired with a striped armchair. A small coffee table sits in front, and a larger dining table is visible in the background. Natural light enters through the nearby window, highlighting the wood-style flooring and soft color palette.
Condo in Monroe City

Moe's Place at Mark Twain Lake

FamilyValueSleep quality

5.0 out of 5 average rating, 27 reviews
Top guest favorite
A comfortable living area features a sectional sofa paired with a lounge chair, both positioned around a coffee table. Light wood flooring complements the neutral walls. A ceiling fan provides ventilation, while natural light enters through the sliding glass doors, partially draped with sheer curtains.
Condo in Monroe City

Mark Twain Lake relaxing getaway

FamilyLocationParking

5.0 out of 5 average rating, 30 reviews
Top guest favorite
The exterior of the condo features a stone-accented façade and a well-maintained lawn. Shrubbery lines the pathway leading to the entrance, while large windows allow natural light to illuminate the interior. A clear blue sky provides a backdrop, enhancing the inviting appearance.
Condo in Quincy

(Front) Location! Clean! Great View! No steps!

ValueFamilyLong stay

4.91 out of 5 average rating, 143 reviews
Condo in Hannibal

Historic luxury townhouse

FamilyLocationCleanliness

5.0 out of 5 average rating, 3 reviews
Guest favorite
The living area features neutral-colored walls and modern flooring. A comfortable, spacious sofa is positioned next to a contemporary coffee table. A flat-screen TV is mounted on the wall opposite a chair and bright window, allowing natural light to fill the room.
Condo in Monroe City

Luxury condo at mark twain

LocationAccessQuiet

4.92 out of 5 average rating, 13 reviewsA scenic view of a lake is shown, with a sandy beach in the foreground. Gentle waves can be seen lapping at the shore, while lush green grass surrounds the area. The sky features a blend of blue and soft cloud formations, indicating a peaceful atmosphere.
Condo in Monroe City

Family Condo By Mark Twain Lake & Jellystone Park

ValueFamilyCleanliness

4.84 out of 5 average rating, 19 reviews
Guest favorite
A serene view from the balcony captures a lush green lawn that gently slopes toward a calm water body. The sky is painted in warm hues of orange and pink as the sun sets, framed by trees on the water's edge.
Condo in Monroe City

Perfect Mark Twain Lake Getaway-condo

FamilyLocationHospitality

4.9 out of 5 average rating, 20 reviewsA living and dining area is shown, featuring a sectional sofa facing a mounted television. A large dining table with eight chairs is positioned nearby. Natural light enters through patterned curtains, and wooden flooring enhances the space's warmth.
Condo in Monroe City

Lovely 2-Bedroom **Ground Level** condo getaway

FamilyLocationWalkability

4.95 out of 5 average rating, 20 reviews

Family-friendly house rentals

Guest favorite
A welcoming living area is furnished with a light gray sofa and a cozy armchair, offering a perfect spot for relaxation. A white-brick fireplace serves as a focal point, while natural light fills the space through multiple windows. A stylish mirror and greenery add decorative touches.
Home in Quincy

Laura’s Simply Charming Cottage

ValueFamilyCleanliness

4.94 out of 5 average rating, 123 reviews
Top guest favorite
A spacious living area features a round coffee table at the center, adorned with a decorative tray and books. Bright natural light filters in through large arched windows, highlighting a cozy sofa and a dining set in the background. A plant adds a touch of greenery.
Home in Quincy

Travelers' Hideaway

LocationValueHospitality

4.92 out of 5 average rating, 100 reviews
Superhost
A well-equipped kitchen features wooden cabinetry and a tiled backsplash. Stainless steel appliances, including a refrigerator and dishwasher, are present. A gas stove is situated next to a dual sink. Natural light enters through nearby windows adorned with light fabric curtains.
Home in Quincy

Charming home, centrally located.

FamilyLocationDecor

4.91 out of 5 average rating, 143 reviews
Guest favorite
Home in Quincy

Spacious Ranch Home at 6533

ValueFamilyIndoor spaces

4.8 out of 5 average rating, 108 reviews
Guest favorite
A spacious sectional sofa with plush cushions is positioned in a well-lit living area. A small table with a lamp and decorative accents complements the seating. Soft tones and minimal décor create a calming environment, enhancing the overall inviting feel of the space.
Home in Quincy

The Modern Ranch Family Home

LocationFamilyKitchen

4.93 out of 5 average rating, 132 reviews
Top guest favorite
The exterior of the home showcases a two-story structure with a pitched roof and a large deck. Comfortable seating is arranged on the deck, surrounded by greenery. The house features a light-colored façade enhancing its welcoming appearance.
Home in Hannibal

Mississippi Sunrise

ValueLocationView

4.95 out of 5 average rating, 74 reviews
Top guest favorite
The exterior of a restored Queen Anne Victorian home showcases intricate architectural details, including a welcoming porch supported by ornate columns. Vibrant greenery surrounds the property, and large windows provide natural light. A gently sloped walkway leads up to the entrance, enhancing the home's historic charm.
Home in Hannibal

The Eleanor Davis House with POOL

ValueLocationCheck-in

4.98 out of 5 average rating, 46 reviews
Guest favorite
A stylish sitting room features a green sofa paired with two armchairs in rich colors. Ambient lighting is provided by table lamps on either side, while large windows are dressed with dark curtains. Decorative plants add a touch of nature, enhancing the room's elegance.
Home in Hannibal

Historic Mansion-close to downtown

FamilyLocationAccess

4.93 out of 5 average rating, 27 reviews

Apartment rentals with air conditioning

Guest favorite
Apartment in Hannibal

House Basement in Hannibal

FamilyLocationLayout

5.0 out of 5 average rating, 15 reviews
Top guest favorite
Apartment in Quincy

Modern Luxe Loft w/ River Views & Private Balcony

FamilyLocationComfort

5.0 out of 5 average rating, 16 reviews
Guest favorite
A spacious living area features a modern sectional sofa complemented by decorative pillows. Exposed brick walls enhance the industrial aesthetic, while large arched windows allow natural light to fill the room. A dining table with chairs can be seen in the background.
Apartment in Quincy

Park View Penthouse

FamilyLocationView

4.92 out of 5 average rating, 59 reviews
Top guest favorite
Apartment in Palmyra

Dent Duplex Two Bedrooms Two Queen beds

ValueFamilyCleanliness

4.95 out of 5 average rating, 22 reviews
Superhost
The kitchen features wooden cabinetry and a white countertop, complemented by a silver sink with a faucet. A white refrigerator and a gas stove are positioned along the wall, with small appliances like a coffee maker on the counter. Flooring is finished in a natural wood tone.
Apartment in Quincy

1237 Hampshire downstairs apartment

ValueLocationLong stay

4.7 out of 5 average rating, 118 reviews
Top guest favorite
A cozy living area is presented, featuring a gray sofa adorned with a blue throw. A light-colored coffee table and side tables are positioned beside the sofa, with a decorative lamp and a tissue box on one. A wall-mounted television rests atop a white console cabinet.
Apartment in Quincy

Eaton's Airbnb D

ValueFamilyBathroom

5.0 out of 5 average rating, 62 reviews
Guest favorite
A comfortable living area is presented with a dark sectional sofa and a matching armchair. A light-colored area rug covers the floor, adding warmth. A television is positioned on a wooden stand against the wall, and natural light enters through a window with simple blinds.
Apartment in Quincy

Hawk’s Nest

ValueLocationHospitality

4.94 out of 5 average rating, 86 reviews
Top guest favorite
A stylish living room features a comfortable sofa and decorative armchairs, arranged around a coffee table. A large television is positioned on a wooden console. Natural light enters through two windows, and a woven wall hanging adds a decorative touch.
Apartment in Quincy

The Stay on State

ValueFamilySleep quality

5.0 out of 5 average rating, 44 reviews

Other great vacation rentals near Mark Twain Boyhood Home and Museum

Guest favorite
A small, remodeled home is visible, set against a backdrop of rolling hills. A wooden deck extends from the entrance, adorned with yellow flowers in planters. Clear skies create a bright atmosphere, enhancing the view of the surrounding landscape.
Tiny home in Hannibal

The View on Reservoir

LocationCheck-inWifi

5.0 out of 5 average rating, 33 reviews
Top guest favorite
Cabin in Quincy

Quincy bay, River front cabin, Best views in town!

ValueLocationQuiet

4.97 out of 5 average rating, 35 reviews
Top guest favorite
Cabin in New London

Chippewa Cottage | Peaceful Woods Near Hannibal

ValueFamilyQuiet

5.0 out of 5 average rating, 52 reviews
Guest favorite
Home in Hannibal

Be Our Guest

LocationComfortKitchen

4.91 out of 5 average rating, 11 reviews
Top guest favorite
A cozy living room is featured, showcasing a light-colored rug and a coffee table surrounded by comfortable seating. Large windows provide natural light and a view of the outdoors. A ceiling fan is positioned above, and soft curtains frame the windows.
Farm stay in New London

The Milkhouse

LocationValueBackyard

5.0 out of 5 average rating, 73 reviews
Top guest favorite
A modern living area features comfortable black recliner sofas arranged around a small wooden table. A television is mounted on the wall across from the sofas, and a well-equipped kitchen is visible in the background, showcasing sleek cabinetry and appliances.
Guesthouse in Hannibal

Quiet/ Relaxing Little Studio

ValueLocationTV

4.93 out of 5 average rating, 84 reviews
Superhost
The kitchen features a large central island with seating for four. Exposed wooden beams enhance the spaciousness. A modern stove, stainless-steel refrigerator, and ample cabinetry provide functional cooking space. Natural light enters through multiple windows, illuminating the warm wood flooring.
Home in Hannibal

Hilltop Farmhouse

LocationFamilyTV

4.75 out of 5 average rating, 16 reviews
Top guest favorite
A cozy living room features a sectional sofa and an oversized ottoman. A television is positioned on a wooden console against a wall adorned with art. Natural light enters through a window with floral curtains, complementing the light wood accents throughout the space.
Home in Quincy

Aunt Lele's Cozy Cottage

LocationValueSolo travel

4.99 out of 5 average rating, 95 reviews

Destinations to explore